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Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans
The impact of endogenous dopamine on in vivo measurement of D2 receptors in humans was evaluated with single photon emission computerized tomography (SPECT), by comparing the binding potential (BP)Expand
Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms.
BACKGROUND Cigarette smoking rates in schizophrenia are higher than in the general population. OBJECTIVES To determine whether cigarette smoking modifies cognitive deficits in schizophrenia and toExpand
A controlled trial of naltrexone augmentation of nicotine replacement therapy for smoking cessation.
BACKGROUND Many smokers remain refractory to current therapies, which only partially address weight gain after smoking cessation. Thus, this study evaluated whether naltrexone hydrochlorideExpand
Psychotherapy and pharmacotherapy for ambulatory cocaine abusers.
BACKGROUND At present, there is no consensus regarding effective treatment for cocaine abuse or the most productive roles for the two major forms of treatment, pharmacotherapy and psychotherapy. WeExpand
Acquisition and maintenance of intravenous cocaine self-administration in Lewis and Fischer inbred rat strains 1 First published on the World Wide Web on 4 November 1997. 1
Lewis and Fischer inbred rat strains differ in behavioral and biochemical responses to psychoactive drugs: Lewis rats show greater behavioral responses to psychoactive drugs than Fischer rats andExpand
Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone—A multiple-dose study
BACKGROUND Simultaneous abuse of cocaine and alcohol is widespread and increasingly detected in patients seeking emergent care. This double-blind, randomized, within-subjects study used a paradigmExpand
Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion.
High concentrations of cocaethylene (EC), the ethyl ester of benzoylecgonine, were measured in the blood of individuals who had concurrently used cocaine and ethanol. Since the powerful reinforcingExpand
Desipramine facilitation of initial cocaine abstinence.
We conducted a double-blind, random assignment, six-week comparison of desipramine hydrochloride (n = 24), lithium carbonate (n = 24), and placebo (n = 24) treatments for cocaine dependence. SubjectsExpand
Oral cocaine: plasma concentrations and central effects.
Cocaine (2.0 milligrams per kilogram) given by the oral route is at least as effective as the same dose given intranasally. Cocaine is not detected in the plasma until 30 minutes after oralExpand
Cocaine and Cocaethylene: Microdialysis Comparison of Brain Drug Levels and Effects on Dopamine and Serotonin
Abstract: Cocaethylene is a pharmacologically active metabolite resulting from concurrent cocaine and ethanol consumption. The effects of cocaine and cocaethylene on extracellular levels of dopamineExpand