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Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
TLDR
It is suggested that the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD and specific pharmacological inhibition of IKK resulted in improved pathology and muscle function in mdx mice. Expand
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
TLDR
Findings indicate that LAMP-2 is critical for autophagy, and this theory is further substantiated by the finding that human Lamp-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes. Expand
Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts.
TLDR
Integrated 3D structural-functional mapping of diseased human right atria ex vivo revealed that the complex atrial microstructure caused significant differences between Endo vs. Epi activation during pacing and sustained AF driven by intramural re-entry anchored to fibrosis-insulated atrial bundles. Expand
A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease
TLDR
The generation of transgenic zebrafish overexpressing mutant Sod1 is reported, which is a vertebrate model of ALS to complement existing mammal models. Expand
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.
TLDR
It is demonstrated that restoration of S100A1 protein levels in failing myocardium by gene transfer may be a novel therapeutic strategy for the treatment of heart failure. Expand
Force, not sarcomere length, correlates with prolongation of isosarcometric contraction.
TLDR
This work studied the timing of twitch contraction in nine excised rat trabeculae to hypothesize that increased force correlates with prolonged Ca2+ binding to troponin-C, and/or 2) attached cross bridges act cooperatively to oppose the inhibiting effects of tropomyosin asCa2+ is lost from the thin filaments. Expand
Small and large animal models in cardiac contraction research: advantages and disadvantages.
TLDR
This review will focus on the cardiac ventricular contractile and relaxation kinetics of humans and animal models in order to illustrate these differences. Expand
Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat.
TLDR
It is concluded that temperature independently affects contraction and relaxation, and cross-bridge cycling kinetics become rate limiting for cardiac relaxation under experimental conditions closest to those in vivo. Expand
Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.
TLDR
NOS1 inhibition or knockout leads to decreased contraction and slowed [Ca2+]i decline, and this effect is absent in PLB-/- myocytes, Thus NOS1 signaling modulates PLB serine16 phosphorylation, in part, via peroxynitrite. Expand
Physiological determinants of contractile force generation and calcium handling in mouse myocardium.
TLDR
Preload, as opposed to increased HR or adrenergic tone, appears to be a much more important determinant of cardiac performance in the mouse than in larger mammals. Expand
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