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- Publications
- Influence
Nitrite and nitrate determinations in plasma: a critical evaluation.
- H. Moshage, B. Kok, J. R. Huizenga, P. Jansen
- Chemistry, Medicine
- Clinical chemistry
- 1 June 1995
Plasma nitrite and nitrate determinations are increasingly being used in clinical chemistry as markers for the activity of nitric oxide synthase and the production of nitric oxide radicals. However,… Expand
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.
- M. Müller, C. Meijer, +5 authors P. Jansen
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 20 December 1994
The multidrug resistance-associated protein (MRP) is a 180- to 195-kDa glycoprotein associated with multidrug resistance of human tumor cells. MRP is mainly located in the plasma membrane and it… Expand
ATP‐ and glutathione‐dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1
- J. Renes, E. D. de Vries, E. Nienhuis, P. Jansen, M. Mueller
- Biology, Medicine
- British journal of pharmacology
- 1 February 1999
The present study was performed to investigate the ability of the multidrug resistance protein (MRP1) to transport different cationic substrates in comparison with MDR1‐P‐glycoprotein (MDR1).… Expand
Increased cancer risk after liver transplantation: a population-based study.
- E. Haagsma, V. E. Hagens, +5 authors P. Jansen
- Medicine
- Journal of hepatology
- 2001
BACKGROUND/AIMS
Development of de novo malignancies emerges as a serious long term complication after liver transplantation.
METHODS
We reviewed the medical records of 174 adult one-year survivors… Expand
Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport
A mutant rat strain is described with autosomal recessive conjugated hyperbilirubinemia. Transport of conjugated bilirubin and tetrabromosulfophthalein from liver to bile is severely impaired whereas… Expand
Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.
- P. Bosma, J. Seppen, +5 authors P. Jansen
- Chemistry, Medicine
- The Journal of biological chemistry
- 8 July 1994
Crigler-Najjar syndrome type I (CN-I) is caused by an inherited absence of UDP-glucuronosyltransferase activity toward bilirubin (B-UGT), resulting in severe non-hemolytic unconjugated… Expand
Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver.
- T. Vos, G. J. Hooiveld, +5 authors M. Müller
- Chemistry, Medicine
- Hepatology
- 1 December 1998
Endotoxin-induced cholestasis is mainly caused by an impaired canalicular secretion. Mrp2, the canalicular multispecific organic anion transporter, is strongly down-regulated in this situation, and… Expand
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport.
- R. O. Oude Elferink, D. Meijer, F. Kuipers, P. Jansen, A. Groen, G. Groothuis
- Biology, Medicine
- Biochimica et biophysica acta
- 17 July 1995
Molecular aspects of hepatobiliary transport.
Generation of bile flow is a regulated, ATP-dependent process and depends on the coordinated action of a number of transporter proteins in the sinusoidal and canalicular domains of the hepatocyte.… Expand
Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats.
- H. Xiong, K. Turner, E. Ward, P. Jansen, K. L. Brouwer
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 November 2000
Previous studies have demonstrated that phenobarbital treatment impairs the biliary excretion of acetaminophen glucuronide (AG), although the transport system(s) responsible for AG excretion into… Expand