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Identification of a specific radioligand for the cardiac rapidly activating delayed rectifier K+ channel.
Class III antiarrhythmic drugs show promise as effective treatments for the suppression of potentially lethal cardiac arrhythmias. Dofetilide (UK-68,798), is a potent class III antiarrhythmic agentExpand
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Structural Variants of Verapamil and W‐7 with Combined Ca2+ Entry Blockade/Myosin Phosphorylation Inhibitory Mechanisms
Arylalkylsulfonamides, identified as Wy-46,622 and Wy-47,324, combine pharmacological properties of the Ca2+ entry blocker verapamil and the calmodulin antagonist W-7. These agents directly inhibitExpand
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Calcium transport by sarcoplasmic reticulum of vascular smooth muscle: II. Effects of calmodulin and calmodulin inhibitors
The role of calmodulin (CaM) in modulating calcium (Ca) uptake by sarcoplasmic reticulum (SR) of vascular smooth muscle was studied in saponin skinned strips of rat caudal artery. Exogenous CaMExpand
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The high temperature aqueous corrosion of ferritic steels: Effect of heat flux on corrosion and magnetite deposition
Abstract A length of 9Cr-1Mo ferritic steel tube has been exposed to a wide range of heat fluxes (0–1389 kW m −2 ) under realistic steam generator conditions (355°C, 17.6 MPa, subcooled boiling toExpand
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Ca2+, calmodulin and cyclic AMP-dependent modulation of actin-myosin interactions in aorta.
Incubation of bovine aortic native actomyosin with cyclic AMP and bovine aortic cyclic AMP-dependent protein kinase produced a rightward shift in the relation between free Ca2+ and bothExpand
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Phosphorylation of myosin light chain in skeletal and smooth muscles.
Significant differences in the properties of myosin light chain phosphorylation in skeletal and smooth muscles may be important in considering the role of myosin phosphorylation in contraction.Expand
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Novel cAMP PDE III inhibitors: 1,6-naphthyridin-2(1H)-ones.
Two series of medorinone (3) analogs were prepared by modifications at C(2) and C(5). The C(2)-series was prepared from 2-chloro-5-methyl-1,6-naphthyridine (4) by replacement of the chloro group withExpand
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Synthetic Heparin Pentasaccharide Depolymerization by Heparinase 1: Molecular and Biological Implications
A synthetic pentasaccharide (SR90107/ ORG31540) representing the antithrombin III (ATIII) binding sequence in heparin is under clinical development for the prophylaxis and management of venousExpand
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Pharmacological Modulation of Cardiac and Vascular Contractile Protein Function
  • P. J. Silver
  • Medicine
  • Journal of cardiovascular pharmacology
  • 1986
The Ca2 + -dependent regulation of contractile protein interactions in cardiac and vascular smooth muscle involves structurally related but distinct Ca2 + binding proteins. In vascular smooth muscle,Expand
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4,5-Dihydro-3-(methanesulfonamidophenyl)-1-phenyl-1H-2,4-benzodiazepines: a novel class III antiarrhythmic agents.
A series of 4,5-dihydro-3-[2-(methanesulfonamidophenyl)ethyl]-1-phenyl- 1H-2,4-benzodiazepines has been identified as potential antiarrhythmic agents that interact at the delayed rectifier myocardialExpand
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