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Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis.
Renal tubular atrophy and interstitial fibrosis are common hallmarks of etiologically different progressive chronic kidney diseases (CKD) that eventually result in organ failure. Even though theseExpand
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Lymphatic phenotype of tumour vessels in malignant gliomas
Malignant gliomas WHO grades III and IV represent some of the most vascularized tumours in humans with poor prognosis despite improvement in conventional therapies. Anaplastic oligodendrogliomas WHOExpand
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Suicide Gene Therapy against Cancer
A major limitation of conventional chemotherapies used in cancer treatments today are low therapeutic indices and side effects that result from drug effects on normal tissues (off target). One of theExpand
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Cytotoxic Markers and Frequency Predict Functional Capacity of Natural Killer Cells Infiltrating Renal Cell Carcinoma
Purpose: Renal cell carcinoma harbors high numbers of infiltrating lymphocytes with apparent limited efficacy in tumor control. This study focused on the natural killer (NK) cells infiltrating renalExpand
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Beneficial Effects of CCR1 Blockade on the Progression of Chronic Renal Allograft Damage
The biology of chemokines and their receptors have been linked to the development of chronic allograft damage. Effects of CCR1 antagonist BX 471 were studied in a Fischer to Lewis renalExpand
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Cell-cycle regulated expression and serine phosphorylation of the myristylated protein kinase C substrate, SSeCKS: Correlation with culture confluency, cell cycle phase and serum response
We recently identified a novel myristylated protein kinase C (PKC) substrate, named SSeCKS (pronounced essex), whose transcription is suppressed >15 fold in src- or ras-transformed rodentExpand
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Sesquiterpene lactones inhibit Yersinia invasin protein-induced IL-8 and MCP-1 production in epithelial cells.
Enteric Yersinia bacteria trigger transcription and secretion of the proinflammatory chemokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in epithelial cells. BothExpand
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A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation.
The expression of chemokines and their receptors is thought to contribute to leukocyte infiltration and progressive renal fibrosis after unilateral ureter obstruction (UUO). We hypothesized thatExpand
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Wnt Pathway Regulation in Chronic Renal Allograft Damage
The Wnt signaling pathway, linked to development, has been proposed to be recapitulated during the progressive damage associated with chronic organ failure. Chronic allograft damage following kidneyExpand
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