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Hypothalamic CART is a new anorectic peptide regulated by leptin
TLDR
It is shown that CART (cocaine- and amphetamine-regulated transcript), a brain-located peptide, is a satiety factor and is closely associated with the actions of two important regulators of food intake, leptin and neuropeptide Y. Expand
Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem
TLDR
Observations substantiate that glucagon-like peptide-1 neurons of the solitary tract constitute a distinct non-catecholaminergic cell group which projects to many targets, one of which is the hypothalamic paraventricular nucleus. Expand
Neurochemical Characterization of Hypothalamic Cocaine—Amphetamine-Regulated Transcript Neurons
TLDR
The present data support a role for CART in neuroendocrine regulation, co-stored with neurotransmitters having both positive (melanin-concentrating hormone) and negative effect on food intake and energy balance. Expand
Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats.
TLDR
In conclusion, GLP-1 may play a physiological role in regulation of both ingestion and the water and salt homeostasis and had no effect in behavioral assays measuring exploratory locomotor activity and conditioned taste aversion. Expand
Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat.
TLDR
It is demonstrated that central administration of the anorectic neuropeptide GLP-1 activates the central CRH-containing neurons of the hypothalamo-pituitary-adrenocortical axis and c-fos expression in these neuroendocrine areas is mediated via specific receptors. Expand
Pituitary Adenylate Cyclase-Activating Peptide (PACAP) in the Retinohypothalamic Tract: A Potential Daytime Regulator of the Biological Clock
TLDR
A new signaling pathway by which the RHT may regulate circadian timing in the daytime as well, through a cAMP-dependent pathway, which could be blocked by a specific cAMP antagonist, Rp-cAMPS. Expand
[The genetics of obesity].
TLDR
Despite a clear genetic cause, the molecular genetic variations underlying common forms of obesity are not clear, and only variations in the MC4R gene have been found with a prevalence which may lead to common form of obesity. Expand
Distribution of GLP‐1 Binding Sites in the Rat Brain: Evidence that Exendin‐4 is a Ligand of Brain GLP‐1 Binding Sites
TLDR
The biochemical data support the idea that the central GLP‐1 receptor resembles the peripheral GLP-1 receptor, and the presence of GLp‐1 binding sites in the circumventricular organs suggests that these may be receptors which act as the target for both peripheral blood‐borne GLP­1 and GLP•1 in the nervous system. Expand
Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour
TLDR
The present experiments suggest that CART peptide exerts its inhibitory effects on appetite by activating hypothalamic and brainstem neurones implicated in the central control of feeding behaviour and metabolism. Expand
Melanopsin is expressed in PACAP-containing retinal ganglion cells of the human retinohypothalamic tract.
TLDR
Given the expression of melanopsin in PACAP-containing RGCs of the human RHT, this photoreceptor is a likely first base in the chain of events leading to photoentrainment of both normal and blind people. Expand
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