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Dopamine and Glutamate Control Area-Restricted Search Behavior in Caenorhabditis elegans
It is demonstrated that dopaminergic and glutamatergic signaling contribute to the neural circuit controlling ARS in the nematode Caenorhabditis elegans, and proposed a mechanism for ARs in C. elegans in which dopamine, released in response to food, modulates glutamating signaling in the locomotory control circuit, thus resulting in an increased turn frequency.
Differential Expression of Glutamate Receptor Subunits in the Nervous System of Caenorhabditis elegans and Their Regulation by the Homeodomain Protein UNC-42
- P. J. Brockie, David M. Madsen, Yi Zheng, Jerry E. Mellem, A. Maricq
- Medicine, BiologyThe Journal of Neuroscience
- 1 March 2001
It is shown that expression of these subunits in this circuit is differentially regulated by the homeodomain protein UNC-42 and that UNC- 42 is also required for axonal pathfinding of neurons in the circuit.
Neuronal Control of Locomotion in C. elegans Is Modified by a Dominant Mutation in the GLR-1 Ionotropic Glutamate Receptor
- Y. Zheng, P. J. Brockie, Jerry E. Mellem, David M. Madsen, A. Maricq
- Biology, MedicineNeuron
- 1 October 1999
Novel perturbation techniques that allow us to depolarize selected neurons in vivo using the dominant glutamate receptor mutation identified in the Lurcher mouse suggest that the gating of movement reversals is controlled in a partially distributed fashion by a small subset of interneurons and that this gating is modified by sensory input.
The C. elegans Glutamate Receptor Subunit NMR-1 Is Required for Slow NMDA-Activated Currents that Regulate Reversal Frequency during Locomotion
- P. J. Brockie, Jerry E. Mellem, T. Hills, David M. Madsen, A. Maricq
- Medicine, BiologyNeuron
- 30 August 2001
It is proposed that NMDA receptors in C. elegans provide long-lived currents that modulate the frequency of movement reversals during foraging behavior and can rescue the nmr-1 mutant phenotype.
Action potentials contribute to neuronal signaling in C. elegans
- Jerry E. Mellem, P. J. Brockie, David M. Madsen, A. Maricq
- Biology, MedicineNature Neuroscience
- 29 June 2008
Small, high-impedance neurons with short processes, similar to those found in the soil nematode Caenorhabditis elegans, are predicted to transmit electrical signals by passive propagation. However,…
Decoding of Polymodal Sensory Stimuli by Postsynaptic Glutamate Receptors in C. elegans
- Jerry E. Mellem, P. J. Brockie, Y. Zheng, David M. Madsen, A. Maricq
- Medicine, BiologyNeuron
- 5 December 2002
It is shown that while the osmotic avoidance response requires both NMDA and non- NMDA receptors, the response to mechanical stimuli only requires non-NMDA receptors.
Evolutionary Conserved Role for TARPs in the Gating of Glutamate Receptors and Tuning of Synaptic Function
It is shown that TARPs are obligate auxiliary subunits for AMPARs with a primary, evolutionarily conserved functional role in the modification of current kinetics.
Wnt Signaling Regulates Acetylcholine Receptor Translocation and Synaptic Plasticity in the Adult Nervous System
A Wnt-signaling pathway is defined that modifies synaptic strength in the adult nervous system by regulating the translocation of one class of acetylcholine receptors to synapses via LIN-17/CAM-1 heteromeric receptors.
Memory in Caenorhabditis elegans Is Mediated by NMDA-Type Ionotropic Glutamate Receptors
A genetic and electrophysiological analysis of learning and memory in the nematode Caenorhabditis elegans shows that two genes are predicted to encode the subunits of an NMDA-type iGluR that is necessary for memory retention in C. elegans and provides new insights into the molecular and cellular mechanisms underlying the memory of a learned event.
Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins.
- C. Walker, P. J. Brockie, +6 authors A. Maricq
- Biology, MedicineProceedings of the National Academy of Sciences…
- 11 July 2006
Ce STG-1 and homologues cloned from Drosophila and Apis mellifera have evolutionarily conserved functions and can partially substitute for one another to reconstitute glutamate-gated currents from rat, Drosophile, and C. elegans.