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Hedgehog signaling in animal development: paradigms and principles.
In their screen for mutations that disrupt the Drosophila larval body plan, these authors identified several that cause the duplication of denticles and an accompanying loss of naked cuticle, characteristic of the posterior half of each segment.
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.
The results strongly support the role for Ci as the transcriptional activator that mediates hh signaling, and identify sequences in the promoter region of the ptc gene that are identical to the consensus-binding sequence of the GLI protein and are required for reporter gene expression in response to Hh activity.
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog.
It is suggested that Shh acts to induce myoblasts committed to slow muscle differentiation from uncommitted presomitic mesoderm to induce slow muscle from medial cells of the somite.
Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos.
Cl cloning of a cDNA from zebrafish encoding a member of the fork head/HNF3 gene family is reported, suggesting that Axial plays a crucial role in specification of both the axial mesendoderm and the ventral central nervous system.
Transducing Hedgehog: the story so far
The secreted proteins of the Hedgehog family have been implicated in many different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we
Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio).
A zebrafish model for Parkin deficiency, the most commonly mutated gene in early onset Parkinson's disease, is developed, making this the first vertebrate model to share both important pathogenic mechanisms and the pathological hallmark with human parkin-mutant patients.
Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish
It is shown that a combination of ectopic echidna hedgehog and sonic hedgehog expression induces supernumary muscle pioneers in wild-type embryos, suggesting that both signals act sequentially to pattern the developing somites.
p53‐dependent neuronal cell death in a DJ‐1‐deficient zebrafish model of Parkinson's disease
The study demonstrates the utility of zebrafish as a new animal model to study PD gene defects and suggests that modulation of downstream mechanisms, such as p53 inhibition, may be of therapeutic benefit.