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A transgenic zebrafish model of neutrophilic inflammation.
It is shown that inflammation is induced after transection of the tail of zebrafish larvae and that this inflammation subsequently resolves over a similar time course to mammalian systems.
The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain.
A new zebrafish mutation is described, neckless, and evidence that it inactivates retinaldehyde dehydrogenase type 2, an enzyme involved in retinoic acid biosynthesis is presented, providing definitive evidence for an involvement of endogenous retinoIC acid in signalling between the paraxial mesoderm and neural tube.
Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo.
It is suggested that positional information is encoded in cell states defined and maintained by the activity of segment polarity gene products.
Mechanisms and functions of Hedgehog signalling across the metazoa
An updated overview of the mechanisms and functions of this signalling pathway is provided, highlighting the conserved and divergent features of the pathway, as well as some of the common themes in its deployment that have emerged from recent studies.
hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila.
The hedgehog (hh) gene plays a role in regulating cell proliferation and specifying cell identity in diverse systems and is expressed at the extreme apical end of Drosophila ovarioles in terminal filament cells and a new group of associated somatic cells.
Elephant shark genome provides unique insights into gnathostome evolution
The whole-genome analysis of a cartilaginous fish, the elephant shark (Callorhinchus milii), finds that the C. milii genome is the slowest evolving of all known vertebrates, and features extensive synteny conservation with tetrapod genomes, making it a good model for comparative analyses of gnathostome genomes.
Role of the Drosophila patched gene in positional signalling
It is shown that the role of patched in positional signalling is permissive rather than instructive, its activity being required to suppress wingless transcription in cells predisposed to express the latter.
Developmental roles and clinical significance of hedgehog signaling.