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In vitro tests and ethnopharmacological investigations: wound healing as an example.
Novel findings are the ability of Buddleja globosa leaf extracts to induce differentiation in keratinocytes and to alter the profile of proteins produced by cultured fibroblasts, and investigations into effects on secondary messengers and protein expression. Expand
The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity.
The sulphorhodamine B (SRB) assay is described in detail as the preferred method and a novel approach has been developed which is based on the hypothesis that, in some circumstances, the naturally occurring compounds act as prodrugs rather than active compounds in their own right. Expand
Omic techniques in systems biology approaches to traditional Chinese medicine research: present and future.
In this short review, omic applications inTCM research are reviewed which has allowed some speculation regarding future perspectives for these approaches in TCM modernisation and standardisation. Expand
Phytochemical Databases of Chinese Herbal Constituents and Bioactive Plant Compounds with Known Target Specificities.
Two databases have been constructed to facilitate applications of cheminformatics and molecular modeling to medicinal plants. The first contains data on known chemical constituents of 240 commonlyExpand
Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin.
The analysis of long-range 13C13C couplings in taxuyunnanine C obtained from an experiment with [U-13C6]glucose documents the involvement of an intramolecular rearrangement in the biosynthesis of the isoprenoid precursor. Expand
Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves.
Most of the species tested had some cytotoxic effect on the cancer cell lines, which to some extent supports their traditional inclusion in herbal preparations for treatment of cancer, which raises concerns over their safety and efficacy in traditional treatment. Expand
Prediction of anti-plasmodial activity of Artemisia annua extracts: application of 1H NMR spectroscopy and chemometrics.
The application of 1H NMR spectroscopy and chemometrics to the analysis of extracts of Artemisia annua allowed the discrimination of samples from different sources, and to classify them according to anti-plasmodial activity without prior knowledge of this activity. Expand
A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion.
Although strong intersubject variation in metabolite profiles was observed, clear differentiation between the samples obtained before and after chamomile ingestion was achieved on the basis of increased urinary excretion of hippurate and glycine with depleted creatinine concentration. Expand
The quest for modernisation of traditional Chinese medicine
This narrative review aims to summarise the findings of the FP7 GP-TCM project, highlight the scientific evidence behind TCM, update the most important milestones and pitfalls, and propose integrity, integration and innovation as key principles for further modernisation of TCM. Expand
Antibacterial and antioxidant cassane diterpenoids from Caesalpinia benthamiana.
The presence of methyl ester and methyl functional groups as well as an unsaturated furan ring appears to confer antibacterial activity and the relatively stronger antioxidant activity of benthaminin 2 may be associated with the presence of an exocyclic methylene function. Expand