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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Increased generation of reactive oxygen species (ROS) and an altered redox status have long been observed in cancer cells, and recent studies suggest that this biochemical property of cancer cellsExpand
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The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo
The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here that mice deficient in the mPer2 gene are cancer prone. After gamma radiation, these mice show a markedExpand
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ROS stress in cancer cells and therapeutic implications.
Reactive oxygen species (ROS) are constantly generated and eliminated in the biological system, and play important roles in a variety of normal biochemical functions and abnormal pathologicalExpand
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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.
Reactive oxygen species (ROS) stimulate cell proliferation and induce genetic instability, and their increase in cancer cells is often viewed as an adverse event. Here, we show that such abnormalExpand
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Co-Creation of Value in a Platform Ecosystem: The Case of Enterprise Software
We examine whether participation in an ecosystem partnership improves the business performance of small independent software vendors (ISVs) in the enterprise software industry and how appropriability mechanisms influence the benefits of partnership. Expand
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Searching for Experience on the Web: An Empirical Examination of Consumer Behavior for Search and Experience Goods
By lowering the costs of gathering and sharing information and offering new ways to learn about products before purchase, the Internet reduces traditional distinctions between search and experienceExpand
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Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism
Cancer cells exhibit increased glycolysis for ATP production due, in part, to respiration injury (the Warburg effect). Because ATP generation through glycolysis is less efficient than throughExpand
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Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ
Mitochondrial DNA (mtDNA) mutations and deletions are frequently observed in cancer, and contribute to altered energy metabolism, increased reactive oxygen species (ROS), and attenuated apoptoticExpand
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Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb.
Crosstalk between the fibroblast growth factor (FGF) and Sonic Hedgehog (Shh) pathways is critical for proper patterning and growth of the developing limb bud. Here, we show that FGF-dependentExpand
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Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish.
We describe an enhancer trap transgenic zebrafish line, ETvmat2:GFP, in which most monoaminergic neurons are labeled by green fluorescent protein (GFP) during embryonic development. The reporter geneExpand
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