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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 × 10−7) was in the… Expand
Newly identified genetic risk variants for celiac disease related to the immune response
This extensive genome-wide association follow-up study has identified additional celiac disease risk variants in relevant biological pathways and identified seven previously unknown risk regions. Expand
Recent advances in coeliac disease
Despite the encouraging progress that has taken place in genetic and immunological knowledge of coeliac disease, early introduction of a gluten-free diet remains the cornerstone of treatment and alternatives aimed at altering the toxicity of cereal proteins are now looking more promising. Expand
Evidence of high sugar intake, and low fibre and mineral intake, in the gluten‐free diet
Aliment Pharmacol Ther 2010; 32: 573–581
Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction.
- H. F. Goode, H. C. Cowley, B. E. Walker, P. Howdle, N. Webster
- Critical care medicine
- 1 April 1995
These data indicate decreased antioxidant status in the face of enhanced free radical activity, and suggest potential therapeutic strategies involving antioxidant repletion. Expand
Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitisAn unusual case of ascites
The results suggest that coeliac disease and ulcerative colitis may share a common aetiology through tight junction-mediated barrier defects, although the observations need further replication. Expand
Primary small-bowel malignancy in the UK and its association with coeliac disease.
- P. Howdle, P. Jalal, G. Holmes, R. Houlston
- QJM : monthly journal of the Association of…
- 1 May 2003
This study provides additional evidence that coeliac disease confers susceptibility to adenocarcinoma of the small bowel, as well as lymphoma, and the long time from the onset of symptoms to diagnosis of small bowel tumours is of concern. Expand
Neurologic complications of liver transplantation in adults
A higher proportion of patients who received transplant for alcoholic liver disease and primary biliary cirrhosis experienced neurologic complications than those receiving transplants for other reasons, and patients who experience a neurologic problem spend longer in hospital and have a poorer outcome. Expand
Advances in celiac disease
The position of proline residues is critical to the toxicity of cereal proteins to patients with celiac disease and other genetic factors, apart from HLA status, remain elusive. Expand
The effects of intravenous antioxidants in patients with septic shock.
- H. Galley, P. Howdle, B. E. Walker, N. Webster
- Chemistry, Medicine
- Free radical biology & medicine
Antioxidant administration may be a useful adjunct to conventional approaches in the management of septic shock and hemodynamic variables has not previously been reported. Expand