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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.
Hypoxia induces rapid and dramatic changes in cellular metabolism, in part through inhibition of target of rapamycin (TOR) kinase complex 1 (TORC1) activity. Genetic studies have shown the tuberousExpand
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TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo
Prostate cancer is the most prevalent cancer in males in developed countries. Tumor suppressor candidate 3 (TUSC3) has been identified as a putative tumor suppressor gene in prostate cancer, thoughExpand
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hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Purpose: Although prognostic and predictive factors in ovarian cancer have been extensively studied for decades, only few have been identified and introduced to clinical practice. Here, we evaluateExpand
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Trail-induced apoptosis and interaction with cytotoxic agents in soft tissue sarcoma cell lines.
Five human soft tissue sarcoma (STS) cell lines (HTB-82 rhabdomyosarcoma, HTB-91 fibrosarcoma, HTB-92 liposarcoma, HTB-93 synovial sarcoma and HTB-94 chondrosarcoma) were analysed for theirExpand
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Loss of the oligosaccharyl transferase subunit TUSC3 promotes proliferation and migration of ovarian cancer cells.
Consequences of deregulated protein N-glycosylation on cancer pathogenesis are poorly understood. TUSC3 is a gene with a putative function in N-glycosylation, located on the short arm of chromosomeExpand
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Abstract 3997: TUSC3 (N33) affects protein N-glycosylation and proliferation of prostate cancer cells
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Prostate cancer is the most prevalent cancer in males in developed countries. Molecular aberrations in the pathogenesisExpand
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N33 (TUSC3) promoter hypermethylation in serum of prostate cancer patients
Proc Amer Assoc Cancer Res, Volume 47, 2006 3241 Genetic and epigenetic alterations both contribute to the pathogenesis of prostate cancer. Methylation induced downregulation of gene expressionExpand
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Fusions in Wild-Type Pancreatic Cancer.
We used whole-genome and transcriptome sequencing to identify clinically actionable genomic alterations in young adults with pancreatic ductal adenocarcinoma (PDAC). Molecular characterization of 17Expand
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Circulating endothelial progenitor cells as biomarker for anti-angiogenic therapy with sunitinib and docetaxel in prostate cancer patients.
e15130 Background: Recent data indicate, that cytotoxic drugs given at MTD in addition to their cytotoxic effects induce mobilization of circulating endothelial progenitor cells (CEP) in drug-free ...