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The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia
TLDR
It is shown that TRPV4 channels are involved in ischemia-induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult. Expand
Heterogeneity of Astrocytes: From Development to Injury – Single Cell Gene Expression
TLDR
To unravel astrocyte heterogeneity during postnatal development and after focal cerebral ischemia, single-cell gene expression profiling was employed in acutely isolated cortical GFAP/EGFP-positive cells to gain insight into the role of glial markers and ion channels/transporters/receptors in maintaining K+ and glutamate homeostasis per cell. Expand
Distinct Expression/Function of Potassium and Chloride Channels Contributes to the Diverse Volume Regulation in Cortical Astrocytes of GFAP/EGFP Mice
TLDR
It is proposed that the diverse volume changes displayed by cortical astrocytes during OGD mainly result from their distinct expression patterns of ClC2 and K2P channels. Expand
Increased expression of hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels in reactive astrocytes following ischemia
TLDR
The expression of Hcn1–4 genes encoding hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels in reactive astrocytes following focal cerebral ischemia or global cerebral isChemia is demonstrated and could be an important therapeutic target in poststroke therapy. Expand
Altered Astrocytic Swelling in the Cortex of α-Syntrophin-Negative GFAP/EGFP Mice
TLDR
The deletion of α-syntrophin markedly alters astrocyte swelling during severe hypoosmotic stress, OGD or high K+. Expand
NMDA Receptors in Glial Cells: Pending Questions
TLDR
This review provides an overview of glial NMDA receptors with respect to ischemic brain injury and focuses on the NMDA receptor subunits present in the particular glial cell types, which give them special characteristics different from those of neurons. Expand
Tamoxifen in the Mouse Brain: Implications for Fate-Mapping Studies Using the Tamoxifen-Inducible Cre-loxP System
TLDR
The results revealed that tamoxifen metabolism in mouse brains is age-, strain- and dose-dependent, and these factors should be taken into account in the experimental design, and this process is influenced by mouse strains, age of animals, and dosage. Expand
Quantitative Analysis of Glutamate Receptors in Glial Cells from the Cortex of GFAP/EGFP Mice Following Ischemic Injury: Focus on NMDA Receptors
TLDR
An overall picture of the gene expression of ionotropic (AMPA, kainate, NMDA) and the main metabotropic glutamate receptors in cortical glial cells isolated from GFAP/EGFP mice before and after focal cerebral ischemia is provided. Expand
Multipotency and therapeutic potential of NG2 cells.
TLDR
The current knowledge about NG2 cells proliferation, their fate plasticity during embryogenesis as well as in postnatal CNS under physiological and pathological conditions are summarized, with the main emphasis on the role of various signaling molecules, growth factors, hormones or even neurotransmitters on the fate potential of NG1 cells. Expand
Neural Stem/Progenitor Cells Derived from the Embryonic Dorsal Telencephalon of D6/GFP Mice Differentiate Primarily into Neurons After Transplantation into a Cortical Lesion
TLDR
After transplantation into the site of a photochemical lesion, D6/GFP-derived NSPCs survive and differentiate into neurons, and their membrane properties are comparable to those transplanted into the non-injured cortex. Expand
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