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In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
TLDR
This work used mesoporous-silica–coated upconversion fluorescent nanoparticles (UCNs) as a nanotransducer to convert deeply penetrating near-infrared light to visible wavelengths and a carrier of photosensitizers to demonstrate in vivo PDT efficacy with the dual-photosensitizer approach. Expand
Herb-drug interactions: a literature review.
Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactionsExpand
The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol
TLDR
Aqueous solubility barrier might affect the speed but not the extent of resveratrol absorption, but, dose manipulation did not have a significant impact on the oral bioavailability of res veratrol. Expand
Gas chromatography/mass spectrometry in metabolic profiling of biological fluids.
TLDR
The applications of GC/MS in the metabolic profiling of urine and blood are discussed, its advances in methodologies and technologies are discussed and its availability of the EI spectral library is discussed. Expand
Pharmacokinetics of pterostilbene in Sprague-Dawley rats: the impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability.
TLDR
Aqueous solubility was identified as a barrier to its oral bioavailability while solubilizing PTS with HP-β-CD substantially increased its bioavailability; dose manipulation was a practical strategy to enhance itsBioavailability and systemic exposure; and its delivery through oral mucosa was feasible. Expand
Mesoporous-silica-coated up-conversion fluorescent nanoparticles for photodynamic therapy.
TLDR
It is demonstrated that the photosensitizers loaded into the porous silica shell of the nanoparticles are not released out of the silica while they continuously produce singlet oxygen upon excitation by a NIR laser. Expand
Noninvasive urinary metabonomic diagnosis of human bladder cancer.
TLDR
One-hundred percent sensitivity in detecting BC was observed using urinary metabonomics versus 33% sensitivity achieved by urinary cytology, and urinary metabolism exhibited potential in the staging and grading of bladder tumors. Expand
Terpenes in propylene glycol as skin-penetration enhancers: permeation and partition of haloperidol, Fourier transform infrared spectroscopy, and differential scanning calorimetry.
The respective alcoholic terpenes carvacrol, linalool, and alpha-terpineol were used at 5% w/v in propylene glycol (PG) to increase the in vitro permeation of haloperidol (HP) through human skin. TheExpand
Urinary metabotyping of bladder cancer using two-dimensional gas chromatography time-of-flight mass spectrometry.
TLDR
The clinical finding on the alteration of the tryptophan-quinolinic metabolic axis in BC suggested the potential roles of kynurenine in the malignancy and therapy of BC and shed new and established insights on the biology of human BC. Expand
Terpenes in ethanol: haloperidol permeation and partition through human skin and stratum corneum changes.
TLDR
Carvacrol was used to enhance the permeation of haloperidol through human skin in vitro and their enhancement mechanism was investigated with HP-stratum corneum (SC) binding studies, fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Expand
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