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BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial.

Heart failure therapy guided by N-terminal BNP did not improve overall clinical outcomes or quality of life compared with symptom-guided treatment, and patients' quality-of-life metrics improved over 18 months of follow-up.
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High frequency of human immunodeficiency virus-associated autonomic neuropathy and more severe involvement in advanced stages of human immunodeficiency virus disease.

The data demonstrate a high prevalence of autonomic neuropathy in HIV-infected patients and that advanced HIV disease is associated with more severe involvement than earlier disease states.
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Closed‐Loop Stimulation Using Intracardiac Impedance as a Sensor Principle: Correlation of Right Ventricular dP/dtmax and Intracardiac Impedance During Dobutamine Stress Test

The results suggest that “inotropy‐sensing” via measurement of intracardiac impedance is highly accurate and seems to be a promising sensor principle for physiological rate adaptation in a closed‐loop pacing system.
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Prevalence of diabetes and impact on cardiovascular events and mortality in patients with chronic coronary syndromes, across multiple geographical regions and ethnicities.

In patients with chronic coronary syndromes, diabetes is independently associated with mortality and cardiovascular events, including heart failure, which is observed across multiple geographic regions and ethnicities, despite marked disparities in the prevalence of diabetes.
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Arrhythmogenic right ventricular cardiomyopathy: diagnostic and prognostic value of the cardiac MRI in relation to arrhythmia-free survival

  • D. KellerS. Osswald Peter T. Buser
  • Medicine, Biology
    The International Journal of Cardiovascular…
  • 1 December 2003
The data suggest that CMR is a highly sensitive and specific method to diagnose or exclude ARVC, and thus, has an important prognostic impact on predicting arrhythmia free survival.
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Rate Response of a Closed‐Loop Stimulation Pacing System to Changing Preload and Afterload Conditions

It is concluded that the rate response of the CLS pacing system can be inappropriately influenced by rapid shifts of blood volume, affecting right ventricular filling.
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[Adrenal cortex and gonadal function in HIV infected patients].

Several studies have demonstrated diminished gonadal or adrenal function in patients infected with the human immunodeficiency virus (HIV). We have evaluated gonadal and adrenal function in 18…
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Primary prevention of Pneumocystis carinii pneumonia by inhalation of pentamidine. Preliminary results from a placebo-controlled randomized trial. Swiss Group for Clinical Studies on AIDS.

Inhalations were well tolerated, with only a 6% use of bronchodilators and a 15% incidence of cough; six patients have developed pneumocystis carinii pneumonia; four of these were on pentamidine, and two on placebo.
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Correlation of Intracardiac Impedance and Right Ventricular Contractility during Dobutamine Stresstest

Investigation of the relationship between changes of intracardiac impedance and RV contractility during incremental dobutamine challenge found it to be an ideal sensor-principle to regulate the chronotropic response of a rate-adaptive pacemaker.

TIME-CHF ) Randomized Trial Elderly Patients With Congestive Heart Failure The Trial of Intensified vs Standard Medical Therapy in BNP-Guided vs Symptom-Guided Heart Failure Therapy :

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