P. Higgins

Publications291
h-index41
Citations6,684
Highly Influential Citations197
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Control selection for RNA quantitation.
The study of mammalian gene expression is often carried out at the level of mRNA. In such analyses, one usually measures the amount of an mRNA of interest under different conditions such as stress,… Expand
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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
p53 limits the proliferation of primary diploid fibroblasts by inducing a state of growth arrest named replicative senescence — a process which protects against oncogenic transformation and requires… Expand
  • 468
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Transcription Factors
Post-translational modifications and subcellular localizations modulate transcription factors, generating a code that is deciphered into an activity. We describe our current understanding of these… Expand
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Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments
We report that experimental autoimmune encephalomyelitis, a T cell-mediated autoimmune disease studied as a model for multiple sclerosis, can be suppressed in Lewis rats by the oral administration of… Expand
  • 194
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TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis
Chronic kidney disease constitutes an increasing medical burden affecting 26 million people in the United States alone. Diabetes, hypertension, ischemia, acute injury, and urological obstruction… Expand
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Reaction of monosaccharides with proteins: possible evolutionary significance.
Measurements were made of the rate of condensation of various monosaccharides with amino groups of hemoglobin to form Schiff base linkages. The reactivity of each sugar was dependent on the extent to… Expand
  • 388
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TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities.
During development of TGF-β1-initiated fibroproliferative disorders, NADPH oxidases (NOX family members) generate reactive oxygen species (ROS) resulting in downstream transcription of a subset genes… Expand
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Kinetic analysis of the nonenzymatic glycosylation of hemoglobin.
The rate constants have been derived for (a) the condensation of glucose with hemoglobin to form the labile Schiff base intermediate, pre-AIc; (b) the dissociation of this complex to hemoglobin and… Expand
  • 136
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A soluble chimeric complement inhibitory protein that possesses both decay-accelerating and factor I cofactor activities.
A chimeric gene was constructed from the genes coding for the human complement regulatory proteins, membrane cofactor protein (CD46) and decay-accelerating factor (CD55). The recombinant chimeric… Expand
  • 71
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TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling.
Transforming growth factor-beta1 (TGF-beta1) transcriptionally regulates the expression of genes that encode specific proteins (e.g., plasminogen activator inhibitor-1; PAI-1) important in stromal… Expand
  • 64
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