• Publications
  • Influence
Hydrophilic interaction liquid chromatography--mass spectrometry for the analysis of paralytic shellfish poisoning (PSP) toxins.
Hydrophilic interaction liquid chromatography was examined for the separation of paralytic shellfish poisoning (PSP) toxins using the stationary phase TSK-gel Amide-80 using a high degree of selectivity and sensitivity.
Multiresidue method for determination of algal toxins in shellfish: single-laboratory validation and interlaboratory study.
A method that uses liquid chromatography with tandem mass spectrometry (LC/MS/MS) has been developed for the highly sensitive and specific determination of amnesic shellfish poisoning toxins,
Relative toxicity of dinophysistoxin-2 (DTX-2) compared with okadaic acid, based on acute intraperitoneal toxicity in mice.
Results from the PP2A assay correspond very well with the results obtained by the mouse bioassay, and supports the establishment of a relative toxicity factor of DTX-2 of 0.6 compared with OA.
Comparative accumulation and composition of lipophilic marine biotoxins in passive samplers and in mussels (M. edulis) on the West Coast of Ireland
It is quite clear from the data that the presence of okadaic acid in the water did not induce toxicity in the transplanted mussels in the absence of phytoplankton, and the SPATT discs accumulated predominantly AZA1 and -2 suggesting that both toxins are biosynthesisized by the AZA-producing organism.
β-N-methylamino-l-alanine (BMAA) and isomers: Distribution in different food web compartments of Thau lagoon, French Mediterranean Sea.
Datoms may be a source of BMAA for mussels, unlike other toxins produced by microalgae, BMAA and DAB were detected in significant amounts in tissues other than digestive glands in mussels.
Marine harmful algal blooms, human health and wellbeing: challenges and opportunities in the 21st century
An overview of different aspects of the HABs phenomena is provided, an important element of the intrinsic links between oceans and human health and wellbeing.
Azaspiracid Shellfish Poisoning: A Review on the Chemistry, Ecology, and Toxicology with an Emphasis on Human Health Impacts
Recent advances on the chemistry of various AZA analogs are discussed, including the putative progenitor algal species, collectively interpret the in vitro and in vivo data on the toxicology of AZAs relating to human health issues, and outline the European legislature associated with AZAs are outlined.
Development of an ultra-performance liquid chromatography-mass spectrometry method for the detection of lipophilic marine toxins.
A rapid method for the detection of marine toxins was developed using an ultra-performance liquid chromatography (UPLC) system coupled to a latest generation mass spectrometry (MS) system and was found to be accurate when using a triplicate methanolic extraction.
The role of Azadinium spinosum (Dinophyceae) in the production of azaspiracid shellfish poisoning in mussels
This is the first report of blue mussels’ feeding on the azaspiracid producing algae A. spinosum from Irish waters and could have implications in the future monitoring of these toxins given that at present according to EU legislation only AZA1–AZA3 is regulated for.
Beta-N-methylamino-l-alanine: LC-MS/MS Optimization, Screening of Cyanobacterial Strains and Occurrence in Shellfish from Thau, a French Mediterranean Lagoon
A combination of an effective solid phase extraction (SPE) clean-up, appropriate chromatographic resolution and the use of specific mass spectral transitions allowed for the development of a highly selective and sensitive analytical procedure to identify and quantify BMAA and its isomers in cyanobacteria and mollusk matrices.