P. Hespel

Publications265
h-index49
Citations8,416
Highly Influential Citations596
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Long-term creatine intake is beneficial to muscle performance during resistance training.
The effects of oral creatine supplementation on muscle phosphocreatine (PCr) concentration, muscle strength, and body composition were investigated in young female volunteers (n = 19) during 10 wk of… Expand
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American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation.
Creatine (Cr) supplementation has become a common practice among professional, elite, collegiate, amateur, and recreational athletes with the expectation of enhancing exercise performance. Research… Expand
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Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans
1 We investigated the effect of oral creatine supplementation during leg immobilization and rehabilitation on muscle volume and function, and on myogenic transcription factor expression in human… Expand
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ACTN3 (R577X) genotype is associated with fiber type distribution.
alpha-Actinin-3 is a Z-disc structural protein found only in type II muscle fibers. The X allele of the R577X polymorphism in the ACTN3 gene results in a premature stop codon and alpha-actinin-3… Expand
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Dietary nitrate improves muscle but not cerebral oxygenation status during exercise in hypoxia.
Exercise tolerance is impaired in hypoxia, and it has recently been shown that dietary nitrate supplementation can reduce the oxygen (O(2)) cost of muscle contractions. Therefore, we investigated the… Expand
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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
HIF prolyl hydroxylases (PHD1–3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of Phd1 lowers oxygen… Expand
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Beta-alanine improves sprint performance in endurance cycling.
PURPOSE Recent research has shown that chronic dietary beta-alanine (betaALA) supplementation increases muscle carnosine content, which is associated with better performance in short (1-2 min)… Expand
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Sprint interval training in hypoxia stimulates glycolytic enzyme activity.
PURPOSE In this study, we compared the effect of sprint interval training (SIT) in normoxia versus hypoxia on muscle glycolytic and oxidative capacity, monocarboxylate transporter content, and… Expand
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Beneficial metabolic adaptations due to endurance exercise training in the fasted state.
Training with limited carbohydrate availability can stimulate adaptations in muscle cells to facilitate energy production via fat oxidation. Here we investigated the effect of consistent training in… Expand
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Aerodynamic study of different cyclist positions: CFD analysis and full-scale wind-tunnel tests.
Three different cyclist positions were evaluated with Computational Fluid Dynamics (CFD) and wind-tunnel experiments were used to provide reliable data to evaluate the accuracy of the CFD… Expand
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