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- Publications
- Influence
Long-term creatine intake is beneficial to muscle performance during resistance training.
- K. Vandenberghe, M. Goris, P. van Hecke, M. van Leemputte, L. Vangerven, P. Hespel
- Medicine
- Journal of applied physiology
- 1 December 1997
The effects of oral creatine supplementation on muscle phosphocreatine (PCr) concentration, muscle strength, and body composition were investigated in young female volunteers (n = 19) during 10 wk of… Expand
American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation.
- R. Terjung, P. Clarkson, +9 authors M. Williams
- Medicine
- Medicine and science in sports and exercise
- 2000
Creatine (Cr) supplementation has become a common practice among professional, elite, collegiate, amateur, and recreational athletes with the expectation of enhancing exercise performance. Research… Expand
Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans
- P. Hespel, B. Op't Eijnde, +6 authors Erik A. Richter
- Biology, Medicine
- The Journal of physiology
- 1 October 2001
1 We investigated the effect of oral creatine supplementation during leg immobilization and rehabilitation on muscle volume and function, and on myogenic transcription factor expression in human… Expand
ACTN3 (R577X) genotype is associated with fiber type distribution.
- B. Vincent, K. De Bock, +4 authors M. Thomis
- Biology, Medicine
- Physiological genomics
- 1 December 2007
alpha-Actinin-3 is a Z-disc structural protein found only in type II muscle fibers. The X allele of the R577X polymorphism in the ACTN3 gene results in a premature stop codon and alpha-actinin-3… Expand
Dietary nitrate improves muscle but not cerebral oxygenation status during exercise in hypoxia.
- E. Masschelein, R. van Thienen, X. Wang, A. Van Schepdael, M. Thomis, P. Hespel
- Medicine
- Journal of applied physiology
- 1 September 2012
Exercise tolerance is impaired in hypoxia, and it has recently been shown that dietary nitrate supplementation can reduce the oxygen (O(2)) cost of muscle contractions. Therefore, we investigated the… Expand
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
- J. Aragonés, M. Schneider, +44 authors P. Carmeliet
- Biology, Medicine
- Nature Genetics
- 1 February 2008
HIF prolyl hydroxylases (PHD1–3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of Phd1 lowers oxygen… Expand
Beta-alanine improves sprint performance in endurance cycling.
- R. van Thienen, K. Van Proeyen, B. Vanden Eynde, J. Puype, Thomas Lefere, P. Hespel
- Medicine
- Medicine and science in sports and exercise
- 1 April 2009
PURPOSE
Recent research has shown that chronic dietary beta-alanine (betaALA) supplementation increases muscle carnosine content, which is associated with better performance in short (1-2 min)… Expand
Sprint interval training in hypoxia stimulates glycolytic enzyme activity.
- J. Puype, K. Van Proeyen, J. Raymackers, L. Deldicque, P. Hespel
- Medicine
- Medicine and science in sports and exercise
- 1 November 2013
PURPOSE
In this study, we compared the effect of sprint interval training (SIT) in normoxia versus hypoxia on muscle glycolytic and oxidative capacity, monocarboxylate transporter content, and… Expand
Beneficial metabolic adaptations due to endurance exercise training in the fasted state.
- K. Van Proeyen, K. Szlufcik, H. Nielens, M. Ramaekers, P. Hespel
- Chemistry, Medicine
- Journal of applied physiology
- 2011
Training with limited carbohydrate availability can stimulate adaptations in muscle cells to facilitate energy production via fat oxidation. Here we investigated the effect of consistent training in… Expand
Aerodynamic study of different cyclist positions: CFD analysis and full-scale wind-tunnel tests.
- T. Defraeye, B. Blocken, E. Koninckx, P. Hespel, J. Carmeliet
- Engineering, Medicine
- Journal of biomechanics
- 7 May 2010
Three different cyclist positions were evaluated with Computational Fluid Dynamics (CFD) and wind-tunnel experiments were used to provide reliable data to evaluate the accuracy of the CFD… Expand