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Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.
We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyte-selective ablation of retinoid X receptors (RXRs) -alpha and -beta in theExpand
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Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma
Atopic dermatitis (AD) is often the initial step in the “atopic march,” given that more than half of AD patients with moderate to severe AD develop asthma later in life. Both AD and asthma share aExpand
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Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade.
Thymic stromal lymphopoietin (TSLP) has emerged as a key initiator in Th2 immune responses, but the TSLP-driven immune cascade leading to Th2 initiation remains to be delineated. Here, by dissectingExpand
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Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin.
human MCs in vitro, and that topical treatment with a 6% miltefosine solution may inhibit IgE-dependent human MC activation in vivo. The in vitro MCstabilizing effect of miltefosine appears not to beExpand
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TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice.
Atopic dermatitis often precedes the development of asthma, a phenomenon known as "atopic march". An important role of allergen sensitization developed through barrier-defective skin has beenExpand
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Counterregulation between thymic stromal lymphopoietin- and IL-23-driven immune axes shapes skin inflammation in mice with epidermal barrier defects.
BACKGROUND Epidermal barrier dysfunction has been recognized as a critical factor in the initiation and exacerbation of skin inflammation, particularly in patients with atopic dermatitis (AD) andExpand
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Treatment of MCPT8DTR mice with high‐ or low‐dose diphtheria toxin leads to differential depletion of basophils and granulocyte‐macrophage progenitors
Basophils have been recently recognized to play important roles in type 2 immune responses during allergies and parasitic infection, largely due to the development of novel tools for the in vivoExpand
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Skin thymic stromal lymphopoietin promotes airway sensitization to inhalant house dust mites leading to allergic asthma in mice
Asthma is often preceded by atopic dermatitis (AD), a phenomenon known as ‘atopic march’. It has been suggested that sensitization to common inhalant allergens, which is developed in a majority ofExpand
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Disrupting the IL-36 and IL-23/IL-17 loop underlies the efficacy of calcipotriol and corticosteroid therapy for psoriasis.
Psoriasis is one of the most common skin inflammatory diseases worldwide. The vitamin D3 analog calcipotriol has been used alone or in combination with corticosteroids in treating plaque psoriasis,Expand
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