• Publications
  • Influence
Membrane transport proteins: implications of sequence comparisons.
Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of relatedExpand
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Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1
Triangulating to Mechanism Cellular uptake and release of a variety of substrates are mediated by secondary transporters, but no crystal structures are known for all three fundamental states of theExpand
  • 184
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Structure and Molecular Mechanism of a Nucleobase–Cation–Symport-1 Family Transporter
The nucleobase–cation–symport-1 (NCS1) transporters are essential components of salvage pathways for nucleobases and related metabolites. Here, we report the 2.85-angstrom resolution structure of theExpand
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Overcoming barriers to membrane protein structure determination
After decades of slow progress, the pace of research on membrane protein structures is beginning to quicken thanks to various improvements in technology, including protein engineering and microfocusExpand
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Unidirectional Reconstitution into Detergent-destabilized Liposomes of the Purified Lactose Transport System of Streptococcus thermophilus*
The lactose transport protein (LacS) of Streptococcus thermophilus was amplified to levels as high as 8 and 30% of total membrane protein in Escherichia coli and S. thermophilus, respectively. InExpand
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Mammalian and bacterial sugar transport proteins are homologous
The uptake of a sugar across the boundary membrane is a primary event in the nutrition of most cells, but the hydrophobic nature of the transport proteins involved makes them difficult toExpand
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Homologous sugar transport proteins in Escherichia coli and their relatives in both prokaryotes and eukaryotes.
  • P. Henderson, M. Maiden
  • Biology, Medicine
  • Philosophical transactions of the Royal Society…
  • 30 January 1990
Separate proteins for proton-linked transport of D-xylose, L-arabinose, D-galactose, L-rhamnose and L-fucose into Escherichia coli are being studied. By cloning and sequencing the appropriate genes,Expand
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Cation and sugar selectivity determinants in a novel family of transport proteins
A new family of homologous membrane proteins that transport galactosides–pentoses–hexuronides (GPH) is described. By analysing the aligned amino acid sequences of the GPH family, and by exploitingExpand
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Subcellular Distribution and Membrane Topology of the Mammalian Concentrative Na+-Nucleoside Cotransporter rCNT1*
The rat transporter rCNT1 is the archetype of a family of concentrative nucleoside transporters (CNTs) found both in eukaryotes and in prokaryotes. In the present study we have used antibodies toExpand
  • 97
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Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins
Significance Drug resistance is an increasing problem in clinical settings with some bacterial pathogens now resistant to virtually all available drugs. Chlorhexidine is a commonly used antisepticExpand
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