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A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis
Primary focal segmental glomerulosclerosis (FSGS) is a disease with poor prognosis and high unmet therapeutic need. Here, we evaluated the safety and pharmacokinetics of single-dose infusions ofExpand
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Cyclosporin in idiopathic glomerular disease associated with the nephrotic syndrome : workshop recommendations.
Management of idiopathic glomerular disease associated with nephrotic syndrome (INS) remains controversial and one of the most complex areas relates to utilization of the drug cyclosporin. This isExpand
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Cytokine removal and cardiovascular hemodynamics in septic patients with continuous venovenous hemofiltration
Objectives: To determine whether continuous venovenous hemofiltration leads to extraction of tumor necrosis factor alpha (TNFα) and cytokines from the circulation of critically ill patients withExpand
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Cardiovascular risk factors and diseases after renal transplantation
Cardiovascular disease is a leading cause of death after renal tranpslantation (tpx), and the incidence is considerably higher than in the general population.ObjectiveTo evaluate the incidence ofExpand
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Reduced incidence of acute renal graft failure in patients treated with peritoneal dialysis compared with hemodialysis.
In a case-control study performed in two centers, the incidence of delayed graft function (DGF), defined as the necessity to perform dialysis after transplantation, was analyzed according to priorExpand
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Systemic mycophenolate mofetil in comparison with systemic cyclosporin A in high-risk keratoplasty patients: 3 years' results of a randomized prospective clinical trial
Abstract. Background: With the use of systemic cyclosporin A (CsA), graft prognosis after high-risk penetrating keratoplasty has improved considerably. However, the application of CsA is limitedExpand
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The "point of no return" and the rate of progression in the natural history of IgA nephritis.
BACKGROUND Based on the observation of 7 patients with chronic IgA nephritis and on a course to end-stage renal failure after several years, D'Amico et al. [1993] reported on a "point of no return"Expand
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Effect of flosulide, a selective cyclooxygenase 2 inhibitor, on passive heymann nephritis in the rat.
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) induce an inhibition of cyclooxygenase (COX), an enzyme that makes prostaglandins. Two isoforms of COX exist: COX-1 represents theExpand
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Systemic ciclosporin A in high-risk keratoplasties
Abstract• Background: It was the purpose of this study to compile the results of all high-risk keratoplasties (kp) performed in our hospital under systemic ciclosporin A (Ci A) cover from 1987Expand
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Comparison of a lactate-versus acetate-based hemofiltration replacement fluid in patients with acute renal failure.
The objective of the study was to determine the impact of a lactate- and an acetate-based hemofiltration replacement fluid (HF) on the acid-base status in patients with acute renal failure (ARF) andExpand
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