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VeA Is Associated with the Response to Oxidative Stress in the Aflatoxin Producer Aspergillus flavus
TLDR
While the osmotic stress response is only slightly affected by the master regulator veA, this gene has a profound effect on the oxidative stress response in the aflatoxin-producing fungus Aspergillus flavus, and it is found that the expression of A. flavus homolog genes involved in the HOG signaling pathway is regulated by veA.
Elucidation of veA-dependent genes associated with aflatoxin and sclerotial production in Aspergillus flavus by functional genomics
TLDR
Microarray technology was used to identify a subgroup of veA-dependent genes that exhibited time-dependent expression profiles similar to those of known aflatoxin biosynthetic genes or that were candidates for involvement in sclerotial production in the wild type.
NsdC and NsdD Affect Aspergillus flavus Morphogenesis and Aflatoxin Production
TLDR
The results suggest that NsdC and NsdD regulate transcription of genes required for early processes in conidiophore development preceding conidium formation, and support previous studies showing that there is a strong association between conidiophileophore and sclerotium development and aflatoxin production in A. flavus.
Characterization of the Aspergillus ochraceoroseus aflatoxin/sterigmatocystin biosynthetic gene cluster
TLDR
The genetic organization of the AF/ST biosynthetic cluster in A. ochraceoroseus is determined and it is demonstrated that it is organized much like the A. nidulans ST gene cluster except that the region from aflN to aflW is located directly upstream of aflC and in reverse orientation such that a flW represents the distal end and aflY the proximal end of the cluster.
The role of Aspergillus flavus veA in the production of extracellular proteins during growth on starch substrates
TLDR
Analysis of starch degradation by fungal enzymes secreted into broths of starch- or corn kernel-based media showed a notable accumulation of glucose in samples of the A. flavus control strain while the deletion veA sample accumulated high levels of maltose and maltotriose and only a small amount of glucose.
The Aspergillus flavus Homeobox Gene, hbx1, Is Required for Development and Aflatoxin Production
TLDR
The results demonstrate that hbx1 not only plays a significant role in controlling A. flavus development but is also critical for the production of secondary metabolites, such as aflatoxins.
Transcriptome Analysis of Aspergillus flavus Reveals veA-Dependent Regulation of Secondary Metabolite Gene Clusters, Including the Novel Aflavarin Cluster
TLDR
The present transcriptome study shows that veA is necessary for the expression of a large number of genes, and predicts that cluster 39 is responsible for the production of aflavarin.
rtfA, a putative RNA-Pol II transcription elongation factor gene, is necessary for normal morphological and chemical development in Aspergillus flavus
TLDR
This study revealed that rtfA controls the expression of the global regulators veA and laeA, which further influence morphogenesis and secondary metabolism in A. flavus and shows that rTFA regulates conidiation.
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