• Publications
  • Influence
vrille, Pdp1, and dClock Form a Second Feedback Loop in the Drosophila Circadian Clock
The Drosophila circadian clock consists of two interlocked transcriptional feedback loops. In one loop, dCLOCK/CYCLE activates period expression, and PERIOD protein then inhibits dCLOCK/CYCLEExpand
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Circadian rhythms from multiple oscillators: lessons from diverse organisms
The organization of biological activities into daily cycles is universal in organisms as diverse as cyanobacteria, fungi, algae, plants, flies, birds and man. Comparisons of circadian clocks inExpand
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Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
Mutations in the period (per) gene of Drosophila melanogaster affect both circadian and ultradian rhythms. Levels of per gene product undergo circadian oscillation, and it is now shown that there isExpand
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How a Circadian Clock Adapts to Seasonal Decreases in Temperature and Day Length
We show that a thermosensitive splicing event in the 3' untranslated region of the mRNA from the period (per) gene plays an important role in how a circadian clock in Drosophila adapts to seasonallyExpand
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The Circadian Timekeeping System of Drosophila
  • P. Hardin
  • Biology, Medicine
  • Current Biology
  • 6 September 2005
Daily rhythms in behavior, physiology and metabolism are controlled by endogenous circadian clocks. At the heart of these clocks is a circadian oscillator that keeps circadian time, is entrained byExpand
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Molecular genetic analysis of circadian timekeeping in Drosophila.
  • P. Hardin
  • Biology, Medicine
  • Advances in genetics
  • 2011
A genetic screen for mutants that alter circadian rhythms in Drosophila identified the first clock gene-the period (per) gene. The per gene is a central player within a transcriptional feedback loopExpand
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PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription.
Transcriptional activation by CLOCK-CYCLE (CLK-CYC) heterodimers and repression by PERIOD-TIMELESS (PER-TIM) heterodimers are essential for circadian oscillator function in Drosophila. PER-TIM wasExpand
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Interlocked feedback loops within the Drosophila circadian oscillator.
Drosophila Clock (dClk) is rhythmically expressed, with peaks in mRNA and protein (dCLK) abundance early in the morning. dClk mRNA cycling is shown here to be regulated by PERIOD-TIMELESSExpand
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dCLOCK Is Present in Limiting Amounts and Likely Mediates Daily Interactions between the dCLOCK–CYC Transcription Factor and the PER–TIM Complex
In Drosophila melanogaster four circadian clock proteins termed PERIOD (PER), TIMELESS (TIM), dCLOCK (dCLK), and CYCLE (CYC/dBMAL1) function in a transcriptional feedback loop that is a core elementExpand
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VRILLE Feeds Back to Control Circadian Transcription of Clock in the Drosophila Circadian Oscillator
The Drosophila circadian oscillator consists of interlocked period (per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops. Within these feedback loops, CLK and CYCLE (CYC)Expand
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