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Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial.
BACKGROUND Irradiation after mastectomy can reduce locoregional recurrences in women with breast cancer, but whether it prolongs survival remains controversial. We conducted a randomized trial ofExpand
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Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy.
We identified the alpha-cardiac actin gene (ACTC) as a novel disease gene in a pedigree suffering from familial hypertrophic cardiomyopathy (FHC). Linkage analyses excluded all the previouslyExpand
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The apolipoprotein E polymorphism in Greenland Inuit in its global perspective
Abstract Apolipoprotein E (apoE) genotypes were determined in Inuit population samples from Nuuk on the south-west coast of Greenland (n = 100) and from the Ammassalik region on the south-east coastExpand
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α-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy
: We identified the alpha-cardiac actin gene (ACTC) as a novel disease gene in a pedigree suffering from familial hypertrophic cardiomyopathy (FHC). Linkage analyses excluded all the previouslyExpand
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Detection of the apoB-3500 mutation (glutamine for arginine) by gene amplification and cleavage with MspI.
A single primer-template mismatch 2 bp from the apoB-3500 (G to A) mutation permits introduction of a cleavage site for MspI (C/CGG) in normal alleles but not in mutant alleles (CCAG). AfterExpand
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Sequential Versus Simultaneous Biventricular Resynchronization for Severe Heart Failure: Evaluation by Tissue Doppler Imaging
Background—Cardiac resynchronization therapy (CRT) by means of simultaneous biventricular pacing improves left ventricular systolic performance and synchrony in patients with heart failure andExpand
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Radiofrequency Ablation as Initial Therapy in Paroxysmal Atrial Fibrillation
*Department of Cardiology, Aarhus University Hospital, Aarhus; and †Gentofte University Hospital, Copenhagen, Denmark; ‡Heart Center, Tampere University Hospital, Tampere, Finland; §LeipzigExpand
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Exaggeration of nonculprit stenosis severity during acute myocardial infarction: implications for immediate multivessel revascularization.
OBJECTIVES This study was designed to assess the prevalence and clinical significance of exaggerated nonculprit lesion stenosis in the setting of acute (<12 h) myocardial infarction (AMI). Expand
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Impact of Substrate Modification by Catheter Ablation on Implantable Cardioverter–Defibrillator Interventions in Patients With Unstable Ventricular Arrhythmias and Coronary Artery Disease: Results
Background— The implantable cardioverter–defibrillator (ICD) is the standard therapy to prevent sudden cardiac death in patients with coronary artery disease and unstable ventricularExpand
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Are men carrying the apolipoprotein ε4- or ε2 allele less fertile than ε3ε3 genotypes?
The ɛ3 allele in the human gene coding for apolipoprotein E (apoE) is the most common worldwide, but ɛ4 is probably the ancestral allele. Since apoE is involved in many important biologicalExpand
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