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Pathophysiology of contrast medium-induced nephropathy.
BACKGROUND Contrast medium-induced nephropathy (CIN) is a well-known cause of acute renal failure, but the development of CIN remains poorly understood. A number of studies have been performed with… Expand
Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension
Aims/hypothesisAugmented formation of reactive oxygen species (ROS) induced by hyperglycaemia has been suggested to contribute to the development of diabetic nephropathy. This study was designed to… Expand
Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes
Aims/hypothesisIncreased oxygen consumption results in kidney tissue hypoxia, which is proposed to contribute to the development of diabetic nephropathy. Oxidative stress causes increased oxygen… Expand
Effect of Intravenous Contrast Media on Proximal and Distal Tubular Hydrostatic Pressure in the Rat Kidney
The effect of i.v. injection of contrast media (CM, 1 600 mg I/kg b.w.) on proximal and distal tubular hydrostatic pressure (PTHP, DTHP) in the rat was investigated using a micropuncture technique.… Expand
Renal failure in 57 925 patients undergoing coronary procedures using iso-osmolar or low-osmolar contrast media.
We compared the Swedish Coronary Angiography and Angioplasty Registry with the Swedish 'Hospital Discharge Register' to assess contrast media (CM)-induced renal failure. Hospitals used only one type… Expand
Diabetes, oxidative stress, nitric oxide and mitochondria function.
The role of altered mitochondria function has recently emerged as an important mechanism for the development of diabetic complications. Altered mitochondria function has also been implicated in the… Expand
Hyaluronan content in the kidney in different states of body hydration.
- P. Hansell, V. Göransson, C. Odlind, B. Gerdin, R. Hällgren
- Kidney international
- 1 November 2000
BACKGROUND Growing evidence suggests that the interstitial hyaluronan (HA) content is a determinant of the fluid exchange barrier in tissues through its high resistance to water flow. This study… Expand
Determinants of kidney oxygen consumption and their relationship to tissue oxygen tension in diabetes and hypertension
- P. Hansell, W. Welch, R. Blantz, F. Palm
- Clinical and experimental pharmacology…
- 1 February 2013
The high renal oxygen (O2) demand is associated primarily with tubular O2 consumption (Qo2) necessary for solute reabsorption. Increasing O2 delivery relative to demand via increased blood flow… Expand
Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells.
- Malou Friederich, A. Fasching, P. Hansell, L. Nordquist, F. Palm
- Biology, Medicine
- Biochimica et biophysica acta
- 1 July 2008
We have previously reported increased O(2) consumption unrelated to active transport by tubular cells and up-regulated mitochondrial uncoupling protein (UCP)-2 expressions in diabetic kidneys. It is… Expand
Activation of hypoxia-inducible factors prevents diabetic nephropathy.
- L. Nordquist, M. Friederich-Persson, +5 authors F. Palm
- Journal of the American Society of Nephrology…
- 1 February 2015
Hyperglycemia results in increased oxygen consumption and decreased oxygen tension in the kidney. We tested the hypothesis that activation of hypoxia-inducible factors (HIFs) protects against… Expand