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Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates.
TLDR
It is demonstrated that colourless mutant neural crest cells form ectomesenchymal fates, which suggests a novel mechanism for the aetiology of Waardenburg-Shah syndrome in which affected neural crest derivatives fail to be generated from the neural crest. Expand
Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva.
TLDR
Analysis of the behavioral defects suggests that these genes participate in the diverse locomotion patterns observed, such as touch response, rhythmic tail movements, equilibrium control, or that they simply confer general motility to the animal. Expand
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish.
TLDR
It is concluded that shh is neither required nor sufficient to induce this cell type in the zebrafish, and ectopic overexpression of shh in zebra fish embryos does not induce ectopic medial floor plate cells. Expand
Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes.
TLDR
The similar and overlapping phenotypes of mutants of the 6 genes identified suggest that they function in a common pathway, which begins in oogenesis, but also depends on factors provided after the onset of zygotic transcription, presumably during blastula stages. Expand
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.
TLDR
It is estimated that the 372 genes defined by the mutants probably represent more than half of all genes that could have been discovered using the criteria of the screen, and the limits and the potentials of a genetic saturation screen in the zebrafish. Expand
Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry.
TLDR
It is suggested that Ndr1 has a role in mesoderm induction, while Ndr2 is involved in subsequent specification and patterning of the nervous system and establishment of laterality. Expand
cyclops encodes a nodal-related factor involved in midline signaling.
TLDR
It is reported that the cyclops locus encodes the nodal-related protein Ndr2, a member of the transforming growth factor type beta superfamily of factors, which is required for ventral midline patterning of the embryonic central nervous system. Expand
Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate
TLDR
The high rate of induction and recovery of point mutations, in addition to an efficient aquarium system to house large numbers of mutagenized lines, means that it is now possible to perform saturation mutagenesis screens in a vertebrate, similar to those done in invertebrates. Expand
Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish.
TLDR
The genes crucial to directing cardiac asymmetry include a subset of those needed for patterning the dorsoventral axis and for notochord and ventral spinal cord development, and appear to be in the pathway by which the heart interprets lateralizing signals from the midline. Expand
The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping.
TLDR
A role for Pitx2 is suggested in promoting looping of the linear heart and gut in mouse, frog and zebrafish embryos and in Xenopus when these organs undergo asymmetric looping morphogenesis. Expand
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