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Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management.
Antipsychotic-induced hyperprolactinaemia should become a focus of interest in the drug treatment of psychiatric patients, particularly given the recent introduction of prolactin-sparing antipsychotics.
A nationwide cohort study of oral and depot antipsychotics after first hospitalization for schizophrenia.
- J. Tiihonen, J. Haukka, Mark Taylor, P. Haddad, Maxine X. Patel, P. Korhonen
- Medicine, PsychologyAmerican Journal of Psychiatry
- 1 June 2011
Use of depot antipsychotics was associated with a significantly lower risk of rehospitalization than use of oral formulations of the same compounds, and clozapine and olanzapine were associated with more favorable outcomes.
Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophrenia
Nonadherence with antipsychotic medication in schizophrenia: challenges and management strategies
Simple pragmatic strategies to improve medication adherence include shared decision-making, regular assessment of adherence, simplification of the medication regimen, ensuring that treatment is effective and that side effects are managed, and promoting a positive therapeutic alliance and good communication between the clinician and patient.
Medicines adherence: Involving patients in decisions about prescribed medicines and supporting adherence
Addressing non-adherence is not about getting patients to take more medicines per se, rather, it starts with an exploration of patients’ perspectives of medicines and the reasons why they may not want or are unable to use them.
Antipsychotic-Related QTc Prolongation, Torsade de Pointes and Sudden Death
It seems prudent, where possible, to select antipsychotics that are not associated with marked QTc prolongation, and if use of a QTC-prolonging drug is warranted, then measures to reduce the risk should be adopted.
The Use of Long-Acting Injectable Antipsychotics in Schizophrenia: Evaluating the Evidence.
The evidence review demonstrated that LAIs are superior to placebo for acute and maintenance treatment of schizophrenia and, in general, appear to be similar to one another in terms of schizophrenia relapse prevention.
Adverse Effects of Atypical Antipsychotics
It is concluded that broad statements comparing the relative risk of specific adverse effects between ‘atypical’ and ‘conventional’ antipsychotics are largely meaningless; rather, comparisons should be made between specific atypical and specific conventional drugs.
Acute and chronic effects of NMDA receptor antagonists in rodents, relevance to negative symptoms of schizophrenia: A translational link to humans
Neurological complications of psychiatric drugs: clinical features and management
Clinicians need to be familiar with strategies to reduce the risk of these adverse events and to manage them when they arise, and their occurrence needs to be balanced against the benefits of psychiatric drugs in terms of efficacy and improved quality of life in a range of disorders.