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Comparison of the metabolism of 2,4-toluenediamine in rats and mice.
The excretion, distribution, and metabolism of 2,4-toluenediamine (TDA) have been compared in rats and mice. The elimination of TDA metabolites into urine was faster and more complete in mice than inExpand
On the sulfate ester of N-hydroxy-N-2-fluorenylacetamide as a key ultimate hepatocarcinogen in the rat.
Evidence is provided that sulfate ester formation constitutes a required second activation step for the expression of carcinogenicity to the liver of rats of N -hydroxy- N -2-fluorenylacetamide, obtained by a first activation step. Expand
Effect of the antioxidant butylated hydroxytoluene (BHT) on the metabolism of the carcinogens N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide.
It is concluded that BHT increases the detoxification metabolites of FAA and N-OH-FAA, and thus lowers the amount of a given dose available for activation reactions. Expand
Participation of liver fractions and of intestinal bacteria in the metabolism of N-hydroxy-N-2-fluorenylacetamide in the rat.
Abstract The level of the active carcinogenic intermediate, N -hydroxy- N -2-fluorenylacetamide (N-OH-FAA) in rats is controlled in part by enzymic reduction to N -2-fluorenylacetamide (FAA). TheseExpand
Enzymic N-acetylation of 2,4-toluenediamine by liver cytosols from various species.
In hamsters and rabbits the highest N-acetyltransferase activity was present in the liver cytosol, followed by kidney intestinal mucosa and lung cytosols, and there was a slight difference in the levels of N- acetyltransferases in males and females. Expand
The effects of a marginally lipotrope-deficient diet on the hepatic levels of S-adenosylmethionine and on the urinary metabolites of 2-acetylaminofluorene in rats.
The altered metabolism of AAF correlated well with the previously reported effects of a marginal lipotrope deficiency on AAF carcinogenesis and caused a transient decrease in hepatic levels of AdoMet. Expand
Identification of new water-soluble metabolites of acetanilide.
Two new urinary metabolites of acetanilide in rats were shown to be the mer-capturic acid derivatives3-[(5-acetamido-2-hydroxyphenyl)thio]-N-acetylalanine and 3-[5- acetamidophenyl)Thio]-n-acetelalanine, which may involve an intermediate expoxide. Expand
Guanethidine N‐oxidation in human liver microsomes
Guanethidine N‐oxidation can be used as a measure of flavin‐containing monooxygenase activity in human liver and is shown to be optimal at pH 8ṁ5 and proceeded at only 16% of the maximal rate at pH 7m̧4. Expand
Metabolism of N-2-fluorenylacetamide in X/Gf mice: lack of correlation between biochemical interaction and carcinogenicity.
A comparative study of the metabolism of the carcinogen N-2-fluorenylacetamide by mice of the X/Gf strain and the NiH Swiss strain showed slight but not outstanding differences in metabolic patterns. Expand