• Publications
  • Influence
Preclinical evaluation of lovastatin.
Administration of lovastatin to animals at high dosage levels produces a broad spectrum of toxicity. This toxicity is expected based on the critical nature of the target enzyme (HMG CoA reductase)Expand
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Feeding Studies in Rats with Mineral Hydrocarbon Food Grade White Oils
This investigation compared the effects of feeding rats diets containing food grade white oil processed by either conventional oleum treatment or the more modem method of catalytic hydrogenation. InExpand
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Wimmera rye grass toxicity in Western Australia.
Outbreaks of Wimmera rye grass toxicity in the south-west of Western Australia, and the associated distribution of Wimmera rye grass parasitised by Anguina sp and Corynebacterium sp wereExpand
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Sheep mortalities associated with the blue green alga Nodularia spumigena.
In 2 field mortalities studied, sheep died and showed haemorrhage and diffuse liver necrosis after drinking water from dams containing growths of the blue green algae Nodularia. Sheep dosed withExpand
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Isolation of a group of glycolipid toxins from seedheads of annual ryegrass Lolium rigidum Gaud.) infected by Corynebacterium rathayi.
A group of highly toxic compounds was isolated from galled seedheads of annual ryegrass (Lolium rigidum Gaud.) containing Corynebacterium rathayi. Purified extracts were resolved by reverse-phaseExpand
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Brain and optic system pathology in hypocholesterolemic dogs treated with a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
The cholesterol lowering compound lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.34 HMG CoA reductase), was given in nine separate experiments toExpand
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Hepatic damage in sheep fed annual ryegrass, Lolium rigidum, parasitised by Anguina agrostis and Corynebacterium rathayi.
Annual ryegrass (Lolium rigidum) parasitised by Anguina agrostis and Corynebacterium rathayi causes neurological signs and brain lesions thought to be associated with a vasoconstrictor effect of theExpand
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Evaluation of the neurotoxic potential of chemicals in animals.
This review provides a scientific view on how to evaluate effectively the neurotoxic potential of chemicals in order to provide adequate safeguards for human health. Detection of compounds that mayExpand
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Morphological changes in the central nervous system of sheep affected with experimental annual ryegrass (Lolium rigidum) toxicity.
Abstract Material from parasitized annual ryegrass ( Lolium rigidum ) (PRG) was dosed to sheep to study changes in the central nervous system in animals affected with annual ryegrass toxicity (ARGT),Expand
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