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Isolation and chemical identification of inhibitors of plasma ligand binding.
The binding by serum albumin of many drugs and endogenous metabolites is impaired in humans and animals with renal failure. Unknown solute(s) retained in renal failure have been extracted from uremicExpand
Plasma hippurate in renal failure: high-performance liquid chromatography method and clinical application.
We have developed a high-performance liquid chromatography (HPLC) method for assay of hippurate in plasma of patients with renal failure. Hippurate accounts, in part, for the impaired binding ofExpand
Comparison of batch and chromatographic assays of cyclic nucleiotide phosphodiesterases.
An improved method for the assay of cyclic nucleotide phosphodiesterases (CNPases) is described in which residual 3H-cAMP or 3H-cGMP is separated from products by chromatography on thin layers ofExpand
Successful seventeen-hour preservation and transplantation of human-cadaver kidney.
ORGAN preservation has been extensively studied for many years, but long-term storage of whole organs is still an unsolved problem. However, short-term preservation of organs such as the kidney wou...
Effect of Renal Homotransplantation on the Metabolism of the Light Chains of Immunoglobulins
Abstract The free light (L) polypeptide chains of human immunoglobulins were measured in the serum and the urine of 14 uremic patients before bilateral nephrectomy, during an anephric period, and a...
Evaluation of amino acid and protein requirements in chronic uremia.
Plasma amino acids were found to deviate extensively from normal in patients with end-stage uremia. Concentrations of all essential amino acids except phenylalanine and methionine were reduced.Expand
Inhibition of cyclic 3',5'-nucleotide phosphodiesterase by adenine compounds.
  • P. Gulyassy
  • Chemistry, Medicine
  • Life sciences. Pt. 2: Biochemistry, general and…
  • 22 April 1971
Abstract Cyclic 3', 5'-nucleotide phosphodiesterase in homogenates of epithelial cells of toad bladders was inhibited by a number of polyvalent anions and adenine-containing compounds. Although ADPExpand