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TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).
Results indicate that TET2 mutations observed in approximately 20% of patients, irrespective of the World Health Organization or French-American-British subtype, represent a molecular marker for good prognosis in MDS. Expand
Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia.
It is suggested that MRD, rather than gene mutations, should be used for future treatment stratifications in CBF-AML patients, as the sole prognostic factor in multivariate analysis. Expand
Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group.
It is indicated that FA patients with mutations in the FANCG gene and patients homozygous for null mutations in FANCA are high-risk groups with a poor hematologic outcome and should be considered as candidates both for frequent monitoring and early therapeutic intervention. Expand
Bromodomain‐dependent stage‐specific male genome programming by Brdt
Bdt is a unique and essential regulator of male germ cell differentiation, which, by using various domains in a developmentally controlled manner, first drives a specific spermatogenic gene expression program, and later controls the tight packaging of the male genome. Expand
Outcome of 69 allogeneic stem cell transplantations for Fanconi anemia using HLA-matched unrelated donors: a study on behalf of the European Group for Blood and Marrow Transplantation.
The dramatic impact of preexisting congenital malformations on the outcome of FA patients transplanted with HLA-matched unrelated donors is shown, and the use of T-cell depletion has led to a dramatic reduction of acute GVHD incidence. Expand
Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells
- Yuichi Morozumi, F. Boussouar, +23 authors S. Khochbin
- Biology, Medicine
- Journal of molecular cell biology
- 1 August 2016
Atad2 is found to be an abundant nucleosome-bound protein present on active genes, associated with chromatin remodelling, DNA replication, and DNA repair factors, and defined as a facilitator of general chromatin-templated activities such as transcription. Expand
Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B.
- Emilie Montellier, F. Boussouar, +20 authors S. Khochbin
- Biology, Medicine
- Genes & development
- 1 August 2013
TH2B is a unique histone variant that plays a key role in the histone-to-protamine packing of the male genome and guides genome-wide chromatin transitions that both precede and follow transmission of themale genome to the egg. Expand
Acute graft-versus-host disease in patients with Fanconi anemia or acquired aplastic anemia undergoing bone marrow transplantation from HLA-identical sibling donors: risk factors and influence on…
The impact of AGvHD on survival may not be limited to the early posttransplantation period and may be a major risk factor for head and neck carcinomas and late mortality in FA patients. Expand
Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway.
Results show that specific analysis of the FA/BRCA pathway, combined with clinical and chromosome breakage data, allows a comprehensive characterization of FA patients. Expand
IL-34 Induces the Differentiation of Human Monocytes into Immunosuppressive Macrophages. Antagonistic Effects of GM-CSF and IFNγ
It is demonstrated that IL-34 drives the differentiation of monocytes into immunosuppressive M2, in a manner similar to M- CSF, and that IFNγ and GM-CSF prevent this effect. Expand