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Pax7 Is Required for the Specification of Myogenic Satellite Cells
The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts and it was demonstrated that satellite cells and muscle-derived stem cells represent distinct cell populations. Expand
Pax-6, a murine paired box gene, is expressed in the developing CNS.
The expression pattern of Pax-6 during embryogenesis and the isolation of cDNA clones spanning the entire coding region are described and, in addition to the paired domain, a paired-type homeodomain is contained. Expand
Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells
It is demonstrated that Pax6 directly controls the transcriptional activation of Retinogenic bHLH factors that bias subsets of RPCs toward the different retinal cell fates, thereby mediating the full retinogenic potential of RPC's. Expand
Pax‐3, a novel murine DNA binding protein expressed during early neurogenesis.
The isolation and characterization of Pax‐3 is described, a novel murine paired box gene expressed exclusively during embryogenesis that specifically recognizes the e5 sequence present upstream of the Drosophila even‐skipped gene. Expand
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.
The isolation of a sequence-related gene referred to as Six3 is reported, which is one of the most anterior homeobox gene reported to date and supports the idea that mammals and insects share control genes such as eyeless/Pax6 and also possibly other members of the regulatory cascade required for eye morphogenesis. Expand
Pax6 Controls Radial Glia Differentiation in the Cerebral Cortex
It is shown that during forebrain neurogenesis, the transcription factor Pax6 is specifically localized in radial glia cells of the cortex but not of the basal telencephalon, suggesting that Pax6 plays an essential role in the differentiation of cortical radialglia. Expand
Roles of Pax-genes in developing and adult brain as suggested by expression patterns
  • A. Stoykova, P. Gruss
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 1 March 1994
The transcript distribution of six members of the murine paired box-containing gene family (Pax-gene family) in midgestation embryo and adult brain using in situ hybridization analysis is examined to suggest a role for Pax-genes in the brain regionalization. Expand
Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system.
The transient nature of Pax2 expression during kidney organogenesis correlates with polarization and induction of epithelial structures and may indicate an important morphogenetic role for this gene. Expand
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye.
Several independent, fully differentiated neuroretinas developed in a single optic vesicle in the absence of a lens, demonstrating that the developing lens is not necessary to instruct the differentiation of the neuroretina but is, rather, required for the correct placement of a single retina in the eye. Expand
Forebrain patterning defects in Small eye mutant mice.
An early restriction of Pax6 and Dlx1 expression into presumptive histogenetic fields that correlate with the formation of distinct forebrain structures and nuclei are found that are consistent with the implications of the prosomeric model for the organisation of the forebrain. Expand