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Benchmarking ortholog identification methods using functional genomics data
BackgroundThe transfer of functional annotations from model organism proteins to human proteins is one of the main applications of comparative genomics. Various methods are used to analyzeExpand
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The impact of calcium, magnesium, zinc, and copper in blood and seminal plasma on semen parameters in men.
To investigate the impact of calcium, magnesium, zinc, and copper in blood and seminal plasma on semen parameters, 107 fertile and 103 subfertile males provided a standardized blood and semenExpand
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Completion of Meiosis I of preovulatory oocytes and facilitation of preimplantation embryo development by glial cell line-derived neurotrophic factor.
Optimal maturation of oocytes and successful development of preimplantation embryos is essential for reproduction. We performed DNA microarray analyses of ovarian transcripts and identified glialExpand
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Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes
BackgroundShortly after stimulation by the preovulatory surge of luteinizing hormone (LH), oocytes arrested at the late prophase I resume meiosis characterized by germinal vesicle breakdown (GVBD),Expand
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Testing statistical significance scores of sequence comparison methods with structure similarity
BackgroundIn the past years the Smith-Waterman sequence comparison algorithm has gained popularity due to improved implementations and rapidly increasing computing power. However, the quality andExpand
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Leptin and ObRa/MEK signalling in mouse oocyte maturation and preimplantation embryo development.
Recent studies indicate that LH stimulates production of ovarian paracrine factors that induce meiosis of the oocyte. DNA microarray analyses of ovarian transcripts were performed in mice and majorExpand
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Conference Scene: Four decades of modern pharmacogenomics: from promise to clinical utility
The World PGX Summit was held in Boston and preceded by a 1-day workshop. The conference aimed at assessing the current ‘state-of-the art’ in advanced molecular profiling strategies for increasedExpand
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Four decades of modern pharmacogenomics: from promise to clinical utility. World PGX Summit 2011. Boston, USA, 26-27 April, 2011.
The World PGX Summit was held in Boston and preceded by a 1-day workshop. The conference aimed at assessing the current 'state-of-the art' in advanced molecular profiling strategies for increasedExpand
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Remote Digital Monitoring for Medical Product Development
Elena S. Izmailova, John A. Wagner, Nadir Ammour, Ninad Amondikar, Andrea Bell-Vlasov, Steven Berman, Dan Bloomfield, Linda S. Brady, Xuemei Cai, Roberto A. Calle, Michelle Campbell, FrancescaExpand