P. Grob

Publications289
h-index30
Citations3,091
Highly Influential Citations43
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Frequent chronic hepatitis B virus infection in HIV-infected patients positive for antibody to hepatitis B core antigen only
Persons with immune deficiency may present with atypical results in serological tests for hepatitis B virus (HBV). Frozen serum specimens that were sequentially obtained over time from a cohort of 57… Expand
  • 186
  • 7
Change in circulating levels of the chemokines macrophage inflammatory proteins 1α and 1β, RANTES, monocyte chemotactic protein‐1 and interleukin‐16 following treatment of severely immunodeficient…
Objective:To evaluate the in vivo relationship between HIV replication and circulating levels of the chemokines macrophage inflammatory protein (MIP)-1α, MIP-1β, RANTES (acronym for Regulated upon… Expand
  • 80
  • 3
Borderline low thyroid function and thyroid autoimmunity. Risk factors for coronary heart disease?
Assessments were made of 945 consecutive hospital patients with regard to a relation between borderline low thyroid function (recognised by a slightly raised thyroid stimulating hormone), thyroid… Expand
  • 104
  • 3
  • PDF
Polyvalent immunoglobulins for prophylaxis of bacterial infections in patients following multiple trauma
One hundred and fifty severely injured patients requiring long-term artificial ventilation were evaluated in a prospective, randomized, double blind study comparing the prophylactic effect of an… Expand
  • 62
  • 3
Immunological abnormalities and HLA antigen frequencies in IgA deficient patients with epilepsy.
Twenty-three epileptics with constitutional factors for seizures and low IgA serum concentrations were studied. Imbalance of the IgG subclasses was often observed, the IgG4 being undetectable in 13… Expand
  • 46
  • 2
Simple monitoring of antiretroviral therapy with a signal‐amplification‐boosted HIV‐1 p24 antigen assay with heat‐denatured plasma
Objective:Virus load determination has become indispensable for the management of HIV patients, but depends on expensive assays of a low throughput. We evaluated whether a highly improved HIV-1 p24… Expand
  • 78
  • 2
Highly active antiretroviral therapy during early HIV infection reverses T‐cell activation and maturation abnormalities
Objectives:To evaluate the impact of early initiation of highly active antiretroviral therapy (HAART) on disease-induced T-cell activation and maturation abnormalities during asymptomatic HIV… Expand
  • 103
  • 2
  • PDF
Highly active antiretroviral therapy during early HIV infection reverses T-cell activation and maturation abnormalities. Swiss HIV Cohort Study.
OBJECTIVES To evaluate the impact of early initiation of highly active antiretroviral therapy (HAART) on disease-induced T-cell activation and maturation abnormalities during asymptomatic HIV… Expand
  • 38
  • 2
Altered intracellular expression of the chemokines MIP‐1α, MIP‐1β and IL‐8 by peripheral blood CD4+ and CD8+ T cells in mild allergic asthma
Background: The ability of chemokines to regulate Th1 and Th2 responses suggests a role in the pathogenesis of atopic disorders such as allergic asthma where Th2 response dominance has been observed.… Expand
  • 33
  • 2
Hepatitis B: virus, pathogenesis and treatment.
  • P. Grob
  • Biology, Medicine
  • Vaccine
  • 1 November 1998
The hepatitis B virus (HBV) is a coated, incompletely double-stranded DNA virus with some outstanding features. (1) All three coat proteins of HBV contain HBsAg, which is highly immunogenic inducing… Expand
  • 24
  • 2