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Cytoplasmic Structures Associated with an Arbovirus Infection: Loci of Viral Ribonucleic Acid Synthesis
High resolution autoradiography demonstrated that the CPV-I are loci of (3)H-uridine incorporation, which correlates well with previous biochemical data and electron microscopy of the subcellular fractions active in Semliki Forest virus ribonucleic acid synthesis. Expand
Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation.
Differences in serine phosphorylation(s) of Stat5a and Stat5b, or Stat5 associations with adaptor proteins or co-transcription factors are other potential sources of functional disparity and the signal amplitude, frequency or duration also can be significant. Expand
Chediak-Higashi syndrome.
Most people with Chediak-Higashi syndrome have repeated and persistent infections starting in infancy or early childhood, which tend to be very serious or lifethreatening. Expand
Simian virus-40 large-T antigen binds p53 in human mesotheliomas
It is found that simian virus 40 (SV40) induces mesotheliomas in hamsters and that 60% of human mesotheiiomas contain and express SV40 sequences2 and that SV40 Tag retains its ability to bind and to inactivate p53, a cellular protein that when normally expressed plays an important role in suppressing tumor growth and in inducing sensitivity to therapy. Expand
Membrane-Associated Replication Complex in Arbovirus Infection
Cytoplasmic extracts of chicken embryo fibroblast cells infected with Semliki Forest virus were subjected to isopycnic centrifugation in discontinuous sucrose gradients. Seven distinct bands wereExpand
Specific Membranous Structures Associated with the Replication of Group A Arboviruses
It is concluded that formation of CPV-1 must result from a virus-specified modification of pre-existing host cell macromolecules. Expand
Extraadrenal retroperitoneal paraganglioma: clinical, pathologic, and CT findings.
It is indicated that extraadrenal retroperitoneal paragangliomas are functionally active more often than previously reported and that they are readily detected by CT as soft-tissue masses closely associated with the entire length of the abdominal aorta. Expand
Prolactin Stimulates Serine/Tyrosine Phosphorylation and Formation of Heterocomplexes of Multiple Stat5 Isoforms in Nb2 Lymphocytes*
Analytical analyses showed that Stat5a and Stat5b respond similarly to prolactin receptor activation, but also suggested that the two genes have evolved unique properties that may contribute to the specificity of receptors that utilize Stat5 signaling proteins. Expand
Activation of the Jak2-Stat5 Signaling Pathway in Nb2 Lymphoma Cells by an Anti-apoptotic Agent, Aurintricarboxylic Acid*
  • H. Rui, Jun Xu, +4 authors P. Grimley
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2 January 1998
It is demonstrated that a single Jak-Stat pathway can be activated by aurintricarboxylic acid (ATA), a negatively charged triphenylmethane derivative with anti-apoptotic properties, and certain hormone or cytokine effects on Jak- Stat pathways can be discretely imitated by a low molecular weight, non-peptide pharmaceutical. Expand