I – Integumentary System
- P. Greaves
- Biology, Medicine
Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation
- P. Greaves
- 29 December 2000
The new 4th edition of "Histopathology of Preclinical Toxicity Studies" is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with…
Adenomyosis--a result of disordered stromal differentiation.
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice
It is shown that a low rather than a high dose of resveratrol prevents tumor growth in mice and alters metabolic pathways in human tissues and suggests that it's time for a revision in development strategies for preventative dietary agents.
Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)
The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice
The results suggest that tricin should be further evaluated as a putative colorectal cancer chemopreventive agent.
Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA…
The hypothesis that green tea catechins or theaflavins from black tea interfere with mammary carcinogenesis in C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma mice and that GTC/BTT affect tumor survival or oxidation status is tested.
Neonatal tamoxifen treatment of mice leads to adenomyosis but not uterine cancer.
Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy
First dose of potential new medicines to humans: how animals help
The principles and the available, albeit limited, evidence that support the design and conduct of preclinical studies in a way that permits effective and safe first-dose studies of potential new medicines in humans are reviewed.