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Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
The ability of betaglycan to facilitate inhibin antagonism of activin provides a variation on the emerging roles of proteoglycans as co-receptors modulating ligand–receptor sensitivity, selectivity and function. Expand
The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.
The crystal structure of BMP7 in complex with the extracellular domain of the activin type II receptor produces a compelling four-receptor model, and finds that truncated receptors lacking their cytoplasmic domain retain the ability to cooperatively assemble in the cell membrane. Expand
Antagonists of activin signaling: mechanisms and potential biological applications
Understanding how activin signaling is controlled extracellularly is the first step in providing treatment for wound healing and for disorders such as cachexia and cancer, which result from a deregulated activin pathway. Expand
Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications.
Growth factors play an important role in the mechanisms involved in myometrial patho-physiology, and are searched for in the database MEDLINE and Google Scholar for articles with content related to growth factors acting on myometrium. Expand
Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins
A new membrane-anchored AKAP targets cAMP-dependent protein kinase to calcium channels and enhances their regulation in multiple cell types. Expand
GRP78 and Cripto Form a Complex at the Cell Surface and Collaborate To Inhibit Transforming Growth Factor β Signaling and Enhance Cell Growth
It is demonstrated that Cripto and GRP78 interact at the cell surfaces of multiple cell lines and that their interaction is independent of prior association within the ER. Expand
Cripto forms a complex with activin and type II activin receptors and can block activin signaling
Cripto can form a complex with activin and ActRII/IIB and inhibition of activin signaling provides an additional example of a Cripto effect on the regulation of signaling by transforming growth factor-β superfamily members. Expand
Identification of distinct inhibin and transforming growth factor beta-binding sites on betaglycan: functional separation of betaglycan co-receptor actions.
It is shown that the inhibin and TGFbeta-binding residues of this domain overlap and individual amino acids essential for binding of each ligand are identified, which will allow the clarification of the role of betaglycan in disease states such as renal cell carcinoma and endometrial adenocarcinoma. Expand
Activins and Inhibins and Their Signaling
Abstract: Activins and inhibins, which were discovered by virtue of their abilities to stimulate or inhibit, respectively, the secretion of FSH, are members of the transforming growth factor‐β (TGFβ)Expand
The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition.
CR-1 performs an essential role in the etiology and progression of several types of human tumors where it is expressed in a population of cancer stem cells (CSCs) and facilitates epithelial-mesenchymal transition (EMT). Expand