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The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis
TLDR
PNPLA3 is associated with an increased risk of advanced fibrosis among patients with a variety of liver diseases and is an independent risk factor for HCC among patientswith nonalcoholic steatohepatitis or alcohol-related cirrhosis. Expand
The Polyploid State Plays a Tumor-Suppressive Role in the Liver.
TLDR
Mechanistically, the diploid state was more susceptible to Cas9-mediated tumor-suppressor loss but was similarly susceptible to MYC oncogene activation, indicating that polyploidy differentially protected the liver from distinct genomic aberrations. Expand
Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer.
TLDR
Mechanistically, loss of Arid1a within tumors decreased chromatin accessibility and reduced transcription of genes associated with migration, invasion, and metastasis, and ARID1A has context-dependent tumor-suppressive and oncogenic roles in cancer. Expand
Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration.
TLDR
Low levels of ANLN messenger RNA were increased in human HCC tissues compared to non-tumor liver tissues and agents that inhibit ANlN in the liver might be effective for prevention or treatment of HCC. Expand
Follicular Dendritic Cell Sarcoma.
TLDR
The clinicopathologic features of follicular dendritic cell sarcoma, recent molecular and cytogenetic findings, prognosis, and current approaches to treatment are discussed. Expand
The changing landscape of hepatocellular carcinoma: etiology, genetics, and therapy.
TLDR
The future of HCC treatment will rely on an understanding of the interplay between etiological factors, molecular features of disease, and rational therapeutic intervention. Expand
Tumor deposits in rectal adenocarcinoma after neoadjuvant chemoradiation are associated with poor prognosis
TLDR
Overall, tumor deposits appear to be a poor prognostic marker among rectal adenocarcinoma patients following neoadjuvant chemoradiation and may identify a subset of patients who require aggressive adjuvant therapy to prevent recurrence. Expand
A Variant in PNPLA3 Associated With Fibrosis Progression but not Hepatocellular Carcinoma in Patients With Hepatitis C Virus Infection.
TLDR
Based on data from the HALT-C trial, the PNPLA3 CG/GG SNP at rs738409 is associated with fibrosis progression but not development of HCC in patients with HCV infection. Expand
The collagenous gastroenteritides: similarities and differences.
TLDR
The etiologies of the collagenous gastroenteritides are not known, so it is not clear whether they are similar because they share pathogeneses, or because they indicate a common histologic response to varying injuries. Expand
Factors that affect accuracy of α-fetoprotein test in detection of hepatocellular carcinoma in patients with cirrhosis.
TLDR
Based on a retrospective analysis of data from patients with cirrhosis, with or without HCC, AFP level most accurately detects HCC in patients without HCV infection. Expand
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