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A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF.
Male development of chromosomally female mice transgenic for Sry
It is shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.
Expression of Sry, the mouse sex determining gene.
This work uses RNase protection to map the extent of the less abundant Sry transcript in the developing gonad and demonstrates that it is a linear mRNA derived from a single exon, which defines the critical period during which Sry must act to initiate Sertoli cell differentiation.
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent…
SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene
- V. Lefebvre, W. Huang, V. Harley, P. Goodfellow, B. de Crombrugghe
- Biology, MedicineMolecular and cellular biology
- 1 April 1997
The results strongly suggest a model whereby SOX9 is involved in the control of the cell-specific activation of COL2A1 in chondrocytes, an essential component of the differentiation program of these cells.
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene
Cloning of a translocation chromosome breakpoint from a sex-reversed patient with campomelic dysplasia, followed by mutation analysis of an adjacent gene, indicates that SOX9, an SRY-related gene, is involved in both bone formation and control of testis development.
A Gene Map of the Human Genome
The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease.
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.
It is demonstrated that Sox-3, as well as Sox-1 and Sox-2, are expressed in the urogenital ridge and that their protein products are able to bind the same DNA sequence motif as Sry in vitro, but with different affinities, suggesting an evolutionary link between the genes.
Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
- S. Silva, A. Hacker, V. Harley, P. Goodfellow, A. Swain, R. Lovell-Badge
- BiologyNature Genetics
- 1 September 1996
It is found that Sox9 expression closely follows differentiation of Sertoli cells in the mouse testis, in experimental sex reversal when fetal ovaries are grafted to adult kidneys and in the chick where there is no evidence for a Sry gene.