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A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wideExpand
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Male development of chromosomally female mice transgenic for Sry
The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biologicalExpand
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A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistentExpand
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Expression of Sry, the mouse sex determining gene.
In the mouse, Sry is expressed by germ cells in the adult testis and by somatic cells in the genital ridge. Transcripts in the former exist as circular RNA molecules of 1.23 kb, which are unlikely toExpand
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SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene.
The identification of mutations in the SRY-related SOX9 gene in patients with campomelic dysplasia, a severe skeletal malformation syndrome, and the abundant expression of Sox9 in mouseExpand
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Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene
Induction of testis development in mammals requires the presence of the Y-chromosome gene SPY. This gene must exert its effect by interacting with other genes in the sex-determination pathway.Expand
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Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
Heterozygous mutations in SOX9 lead to a human dwarfism syndrome, Campomelic dysplasia. Consistent with a role in sex determination, we find that Sox9 expression closely follows differentiation ofExpand
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A Gene Map of the Human Genome
The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized toExpand
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A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.
The Sox gene family consists of a large number of embryonically expressed genes related via the possession of a 79-amino-acid DNA-binding domain known as the HMG box. Partial clones for the firstExpand
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A method for constructing radiation hybrid maps of whole genomes
In radiation hybrid mapping, chromosomes in human–rodent hybrid cells are fragmented by X–rays and fragments rescued by fusion of the donor cell to a recipient rodent cell. The co–retentionExpand
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