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Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex.
An oculomotor delayed-response task was used to examine the spatial memory functions of neurons in primate prefrontal cortex and found that inhibitory responses were usually strongest for, or centered about, cue directions roughly opposite those optimal for excitatory responses.
Cellular basis of working memory
Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model.
A network model endowed with a columnar architecture and based on the physiological properties of cortical neurons and synapses finds that recurrent synaptic excitation should be primarily mediated by NMDA receptors, and that overall recurrent synaptic interactions should be dominated by inhibition.
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.
Dual streams of auditory afferents target multiple domains in the primate prefrontal cortex
Injection of multiple tracers into physiologically mapped regions AL, ML and CL of the auditory belt cortex revealed that anterior belt cortex was reciprocally connected with the frontal pole, rostral principal sulcus and ventral prefrontal regions.
Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey
The present findings suggest a new conceptualization of corticostriatal topography in the primate which emphasizes the longitudinal arrangement of cortical terminal domains, and provide a map for functional parcellation of the neostriatum on the basis of its cortical innervation.
Heterogeneity in the pyramidal network of the medial prefrontal cortex
Multineuron patch-clamp recordings in the ferret medial prefrontal cortex showed a heterogeneity of synapses interconnecting distinct subnetworks of different pyramidal cells, which could amplify recurrent interactions between pyramides and support persistent activity in the prefrontal cortex.
Topography of cognition: parallel distributed networks in primate association cortex.
The structure and functions of the frontal lobes, particularly the prefrontal "silent" portion, have recently again become the subject of intense interest and the availability of solid new findings in experimental animals and human patients and the promise of further discoveries are undoubtedly the basis of this renewed interest.
Dissociation of object and spatial processing domains in primate prefrontal cortex.
These findings indicate that the prefrontal cortex contains separate processing mechanisms for remembering "what" and "where" an object is.
Posterior parietal cortex in rhesus monkey: II. Evidence for segregated corticocortical networks linking sensory and limbic areas with the frontal lobe
The main finding is that each subdivision of parietal cortex is connected with a unique set of frontal areas, and although they are most prominent within a hemisphere, notable interhemispheric connections are also present.