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Eosinophilic inflammation in asthma.
TLDR
Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease. Expand
Induction of nitric oxide synthase in asthma
TLDR
The existence of inducible NO synthase in human lungs suggests that increased production of NO, probably induced by cytokines, may be relevant to the pathology of asthma. Expand
The public health implications of asthma.
TLDR
A model of asthma costs is needed to aid attempts to reduce them while permitting optimal management of the disease and a model to predict the costs incurred by the disease is proposed. Expand
Rhinosinusitis in severe asthma.
TLDR
Frequency of rhinosinusitis in patients with mild-to-moderate or severe steroid-dependent asthma is similar; however, sinonasal involvement, as evaluated by clinical symptoms and CT scan imaging, is significantly greater in the patients with severe steroid -dependent asthma than in those with mild, to-moderate asthma. Expand
Drug Provocation Tests in Patients with a History Suggesting an Immediate Drug Hypersensitivity Reaction
TLDR
Evaluating the outcomes of more than 1300 drug provocation tests performed on more than 800 patients with histories suggesting immediate drug allergy found them to be a safe method for confirming immediate hypersensitivity. Expand
Correlation between symptoms and the threshold for release of mediators in nasal secretions during nasal challenge with grass-pollen grains.
TLDR
Prostaglandin D2 (PGD2) was assayed with an enzyme immunoassay with a polyclonal antibody against PGD2 methoxamine and the release of PGD 2 was significantly correlated with a symptom score of 5, which increased 3.7-fold after a positive nasal challenge. Expand
Chest radiography and high resolution computed tomography of the lungs in asthma.
TLDR
To discriminate between reversible and irreversible CT-scan abnormalities, two examinations were made in 10 patients with acute asthma both before and 2 wk after parenteral high dose corticosteroid treatment to determine whether bronchial destructive lesions may be observed. Expand
Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease.
TLDR
The percentages of neutrophils in BALF were greater in patients with COPD than in those with CB, suggesting a role in the chronic airflow limitation. Expand
Release of cytokines by blood monocytes during strenuous exercise.
TLDR
Correlations were observed between the in vitro release of IL-6 or TNF-alpha and age, VO2max, maximal ventilation and maximal power output of the subjects, and there was no correlation between the release ofIL-6 and TNF -alpha and lung function measured during hypoxemia. Expand
Randomised, placebo controlled trial of effect of a leukotriene receptor antagonist, montelukast, on tapering inhaled corticosteroids in asthmatic patients
TLDR
Montelukast reduces the need for inhaled corticosteroids among patients requiring moderate to high doses of corticosterone to maintain asthma control, and many patients receive higher doses of inhaled Corticosteroid than clinically required. Expand
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