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Migraine--current understanding and treatment.
Migraine is a common and sometimes debilitating disorder. This review describes the epidemiology, pathophysiology, and preventive and symptomatic treatment of migraine, with special attention to drug… Expand
A review of paroxysmal hemicranias, SUNCT syndrome and other short-lasting headaches with autonomic feature, including new cases.
The short-lasting primary headache syndromes may be conveniently divided into those exhibiting marked autonomic activation and those without autonomic activation. The former group comprise chronic… Expand
Oral triptans (serotonin 5-HT1B/1D agonists) in acute migraine treatment: a meta-analysis of 53 trials
BACKGROUND The triptans, selective serotonin 5-HT(1B/1D) agonists, are very effective acute migraine drugs with a well- developed scientific rationale. Seven different triptans will soon be… Expand
Pathophysiology of Migraine: A Disorder of Sensory Processing.
- P. Goadsby, P. Holland, M. Martins-Oliveira, J. Hoffmann, C. Schankin, S. Akerman
- Physiological reviews
- 1 April 2017
Plaguing humans for more than two millennia, manifest on every continent studied, and with more than one billion patients having an attack in any year, migraine stands as the sixth most common cause… Expand
Central nervous system mechanisms of pain
Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study
- J. Saper, D. Dodick, S. Silberstein, Sally E McCarville, Mark G. F. Sun, P. Goadsby
- Cephalalgia : an international journal of…
- 1 February 2011
Background: Medically intractable chronic migraine (CM) is a disabling illness characterized by headache ≥15 days per month. Methods: A multicenter, randomized, blinded, controlled feasibility study… Expand
Pathophysiology of migraine
- P. Goadsby
- Annals of Indian Academy of Neurology
- 1 August 2012
Migraine is a common disabling brain disorder whose pathophysiology is now being better understood. The study of anatomy and physiology of pain producing structures in the cranium and the central… Expand
CGRP and its receptors provide new insights into migraine pathophysiology
Over the past 300 years, the migraine field has been dominated by two main theories—the vascular theory and the central neuronal theory. The success of vasoconstrictors such as ergotamine and the… Expand
Recent advances in understanding migraine mechanisms, molecules and therapeutics.
- P. Goadsby
- Trends in molecular medicine
Migraine is a complex, disabling disorder of the brain that manifests itself as attacks of often severe, throbbing head pain with sensory sensitivity to light, sound and head movement. There is a… Expand
Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study.
- M. Matharu, T. Bartsch, N. Ward, R. Frackowiak, R. Weiner, P. Goadsby
- Brain : a journal of neurology
Electrical stimulation of primary sensory afferents is known to have an antinociceptive effect. Animal and functional imaging studies suggest a role for supraspinal structures in this response. Eight… Expand