Migraine--current understanding and treatment.
The epidemiology, pathophysiology, and preventive and symptomatic treatment of migraine is described, with special attention to drug therapy with the triptans.
Pathophysiology of Migraine: A Disorder of Sensory Processing.
- P. Goadsby, P. Holland, M. Martins-Oliveira, J. Hoffmann, C. Schankin, S. Akerman
- BiologyPhysiological Reviews
- 1 April 2017
Investment in understanding migraine leaves us at a new dawn, able to transform its impact on a global scale, as well as understand fundamental aspects of human biology.
Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
A substantial elevation of the calcitonin gene‐related peptide level in the external jugular but not the cubital fossa blood was seen in both classic and common migraine, and may have importance in the pathophysiology of migraine.
Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine.
The CGRP antagonist BIBN 4096 BS was effective in treating acute attacks of migraine and showed significant superiority over placebo with respect to most secondary end points.
Oral triptans (serotonin 5-HT1B/1D agonists) in acute migraine treatment: a meta-analysis of 53 trials
The International Classification of Headache Disorders: 2nd edition
EFNS guidelines on the treatment of cluster headache and other trigeminal‐autonomic cephalalgias
Large series suggest that lamotrigine is the most effective preventive agent, with topiramate and gabapentin also being useful in treatment of SUNCT syndrome, and surgical procedures, although in part promising, require further scientific evaluation.
A Controlled Trial of Erenumab for Episodic Migraine
Erenumab administered subcutaneously at a monthly dose of 70 mg or 140 mg significantly reduced migraine frequency, the effects of migraines on daily activities, and the use of acute migraine–specific medication over a period of 6 months.
Cluster headache: A prospective clinical study with diagnostic implications
Patients with cluster headache offer a population of primary headache patients with devastating acute attacks of pain and the syndrome is stereotyped with effective evidence-based treatments that are prescribed in only half of patients having cluster headache.
Pathophysiology of migraine
- P. Goadsby
- Medicine, BiologyAnnals of Indian Academy of Neurology
- 1 December 2006
Understanding the pathophysiology of migraine is integral to providing explanations to patients and good management strategies, and its therapy involves reducing afferent traffic or stabilizing these abnormal pathways.