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Migraine--current understanding and treatment.
The epidemiology, pathophysiology, and preventive and symptomatic treatment of migraine is described, with special attention to drug therapy with the triptans. Expand
Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine.
The CGRP antagonist BIBN 4096 BS was effective in treating acute attacks of migraine and showed significant superiority over placebo with respect to most secondary end points. Expand
Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
A substantial elevation of the calcitonin gene‐related peptide level in the external jugular but not the cubital fossa blood was seen in both classic and common migraine, and may have importance in the pathophysiology of migraine. Expand
Oral triptans (serotonin 5-HT1B/1D agonists) in acute migraine treatment: a meta-analysis of 53 trials
BACKGROUND The triptans, selective serotonin 5-HT(1B/1D) agonists, are very effective acute migraine drugs with a well- developed scientific rationale. Seven different triptans will soon beExpand
Triptans (Serotonin, 5-HT1B/1D Agonists) in Migraine: Detailed Results and Methods of A Meta-Analysis of 53 Trials
An evidence-based foundation is provided for using triptans in clinical practice, and the methodological issues surrounding triptan trials are reviewed, including the choice of the primary endpoint, consistency over multiple attacks, how to evaluate headache recurrence, use of placebo-subtracted proportions to control for across-study differences, andthe difference between tolerability and safety. Expand
EFNS guidelines on the treatment of cluster headache and other trigeminal‐autonomic cephalalgias
Large series suggest that lamotrigine is the most effective preventive agent, with topiramate and gabapentin also being useful in treatment of SUNCT syndrome, and surgical procedures, although in part promising, require further scientific evaluation. Expand
The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
These data characterize some aspects of the cerebrovascular physiology of the trigeminovascular system and demonstrate important interactions between this system and the effective antimigraine agents sumatriptan and dihydroergotamine and that such interactions can be represented in animal models. Expand
EFNS guideline on the drug treatment of migraine – revised report of an EFNS task force
Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients’ quality of life and the use of medication to treat it is a major concern. Expand