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PLGA microspheres for the ocular delivery of a peptide drug, vancomycin using emulsification/spray-drying as the preparation method: in vitro/in vivo studies.
Poly(lactide-co-glycolide) microspheres were able to modulate the in vitro drug release of VA with a behavior dependent on their composition: the highest drug content corresponded to the highest release rate.
Nasal administration of carbamazepine using chitosan microspheres: in vitro/in vivo studies.
The results obtained indicate that the loading of CBZ in chitosan glutamate microspheres increases the amount of the drug absorbed through the nose.
Mucoadhesive microspheres for nasal administration of an antiemetic drug, metoclopramide: in‐vitro/ex‐vivo studies
It is shown that alginate/chitosan spray‐dried microspheres have promising properties for use as mucoadhesive nasal carriers of an antiemetic drug.
Spray-drying as a preparation method of microparticulate drug delivery systems: an overview
La nebulisation est une technologie recemment utilisee pour la preparation de microparticules: microspheres et microcapsules. Differents procedes sont passes en revue, avec une attention particuliere
Brain uptake of an anti-ischemic agent by nasal administration of microparticles.
Ex vivo studies on sheep nasal mucosa and in vitro mucoadhesion studies indicated that CPA-loaded chitosan microparticles had higher mucocoadhesive properties compared to mannitol particles, which can open new perspectives for the employment of CPA against brain damages following stroke.
Chitosan gels for the vaginal delivery of lactic acid: Relevance of formulation parameters to mucoadhesion and release mechanisms
The aim of this work was to assess the effect of formulation parameters of a mucoadhesive vaginal gel based on chitosan and lactic acid, and to highlight its release mechanisms. Two molecular weight
Spray-dried microspheres based on methylpyrrolidinone chitosan as new carrier for nasal administration of metoclopramide.
Preliminary results show that spray-dried microspheres based on MPC could be a suitable nasal delivery system for the administration of metoclopramide.
Emulsion Spray-Drying for the Preparation of Albumin-Loaded PLGA Microspheres
Results showed that the emulsion/spray-drying method is suitable for obtaining small microparticles characterized by high drug payloads (70%–80% encapsulation efficiency) and the type of surfactant affects the microsphere shape and BSA release behavior.
Encapsulation and modified-release of thymol from oral microparticles as adjuvant or substitute to current medications.
Methylcellulose microspheres can be used for thymol systemic administration at low doses and HPMCP particles for local treatment of intestinal infections and could be proposed as alternative or adjuvants for controlling pathogen infections in human or animal.
Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres.
The determination of chlorhexidine in saliva showed the capacity of these formulations to give a prolonged release of the drug in the buccal cavity and the improvement is particularly high against Candida albicans.