P. Gigon

Publications26
h-index11
Citations966
Highly Influential Citations6
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Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH.
Effect of partial hepatectomy of the responsiveness of microsomal enzymes and cytochrome P-450 to phenobarbital or 3-methylcholanthrene.
Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylation.
Interference of UDP-glucuronyltransferase and beta-glucuronidase activity in rat liver microsomes at pH 7.5 with p-nitrophenol and p-nitrophenylglucuronide as substrates.
TLDR
Microsomal fraction contains the whole of hepatic UDP-glucuronyltransferase as well as part of beta-glUCuronidase, and was assayed under identical conditions using untreated male rat liver microsomes at pH 7.5.
Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
TLDR
The data suggest that the complexes formed between cytochrome P-450 and type I compounds are more readily reduced by NADPH than is the endogenous hemoprotein.
The distribution of the components of mixed-function oxidase between the rough and the smooth endoplasmic reticulum of liver cells.
TLDR
The results suggest that, in the rabbit, the rate-limiting step is the reduction of cytochrome P-450, and in the rat the difference in activities can be explained by differences in the concentration of cy tochromeP-450.
Sex differences in the kinetic constants for the N-demethylation of ethylmorphine by rat liver microsomes.
Changes in Michaelis and spectral constants for aniline in hepatic microsomes from phenobarbital-treated rats.
TLDR
It was found that the Michaelis constant and binding constant for aniline differ by a factor of 10 in microsomal preparations from intact animals, and phenobarbital treatment was found to elicit significant increases in both K[unknown] , and Km forAniline, implying that induction by phenobarBital may be associated with qualitative as well as quantitative changes in the hepaticmicrosomal anilines hydroxylase.
Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyzes ethylmorphine metabolism.
N-demethylation and N-oxidation of imipramine by rat and pig liver microsomes.
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