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A diet low in FODMAPs reduces symptoms of irritable bowel syndrome.
TLDR
In a controlled, cross-over study of patients with IBS, a diet low in FODMAPs effectively reduced functional gastrointestinal symptoms and high-quality evidence supports its use as a first-line therapy.
Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis.
TLDR
Golimumab (50 mg or 100 mg) maintained clinical response through week 54 in patients who responded to induction therapy with golimumab and had moderate-to-severe active ulcerative colitis; patients who received 100 mg Golimumab had clinical remission and mucosal healing at weeks 30 and 54.
No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates.
TLDR
In a placebo-controlled, cross-over rechallenge study, there is no evidence of specific or dose-dependent effects of gluten in patients with NCGS placed diets low in FODMAPs.
Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis.
TLDR
Treatment with subcutaneous golimumab induces clinical response, remission, and mucosal healing, and increases quality of life in larger percentages of patients with active UC than placebo.
Evidence‐based dietary management of functional gastrointestinal symptoms: The FODMAP approach
TLDR
The evidence base for restricting rapidly fermentable, short‐chain carbohydrates (FODMAPs) in controlling functional gastrointestinal symptoms is described.
Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease: A Double-Blind Randomized Placebo-Controlled Trial
TLDR
“Non-celiac gluten intolerance” may exist, but no clues to the mechanism were elucidated and there were no differences in any end point in individuals with or without DQ2/DQ8.
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome
TLDR
Reduction of short‐chain poorly absorbed carbohydrates (FODMAPs) in the diet reduces symptoms of irritable bowel syndrome, and symptoms produced in response to diets that differed only in FODMAP content are compared.
Diets that differ in their FODMAP content alter the colonic luminal microenvironment
TLDR
A low FODMAP diet reduces symptoms of IBS, but reduction of potential prebiotic and fermentative effects might adversely affect the colonic microenvironment, and diets differing in FodMAP content have marked effects on gut microbiota composition.
Systematic review: exercise‐induced gastrointestinal syndrome—implications for health and intestinal disease
“Exercise‐induced gastrointestinal syndrome” refers to disturbances of gastrointestinal integrity and function that are common features of strenuous exercise.
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