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Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease
TLDR
New stereologic data indicate that neuronal pathology in hippocampal formation and frontal cortex closely reflects the progression of cognitive deficits in brain aging and AD, and demonstrate that amyloid volume has no additional predictive value, in terms of clinicopathologic correlations, beyond its interaction with NFT.
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Distinction between Perceptual and Attentional Processing in Working Memory Tasks: A Study of Phase-locked and Induced Oscillatory Brain Dynamics
TLDR
A time-frequency analysis of the 3 to 30 Hz EEG oscillatory activity in a verbal n-back working memory paradigm is proposed, providing further functional information on the fronto-posterior network supporting working memory.
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Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
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Pain in Severe Dementia: Self‐Assessment or Observational Scales?
OBJECTIVES: To assess the performance of self‐assessment scales in severely demented hospitalized patients and to compare it with observational data.
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Evidence-Based Guidelines for Mental, Neurological, and Substance Use Disorders in Low- and Middle-Income Countries: Summary of WHO Recommendations
TLDR
The recent WHO Mental Health Gap Action Programme (mhGAP) intervention guide that provides evidence-based management recommendations for mental, neurological, and substance use disorders is summarized.
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Individual prediction of cognitive decline in mild cognitive impairment using support vector machine-based analysis of diffusion tensor imaging data.
TLDR
SVM analysis of DTI data provided highly accurate individual classification of stable versus progressive MCI regardless of MCI subtype, indicating that this method may become an easily applicable tool for early individual detection ofMCI subjects evolving to dementia.
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Age-associated modulations of cerebral oscillatory patterns related to attention control
View on Elsevier
Anterior cingulate cortex pathology in schizophrenia and bipolar disorder
TLDR
Mean total and laminar cortical thicknesses as well as mean pyramidal neuron size were significantly decreased in the dorsal and subgenual parts of areas 24 (24sg) in schizophrenic cases, whereas patients with major depression were comparable to controls.
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Clinical validity of Braak neuropathological staging in the oldest-old
TLDR
The present data suggest that the substantial involvement of the hippocampus which characterizes Braak stage IV is a key step in the development of overt clinical signs of dementia in the oldest-old and indicate that Braak staging represents a broad concept of the evolution of neurofibrillary tangles rather than a precise hierarchical model associated with a stepwise deterioration of cognitive abilities near the upper limit of life.
View on Springer
Review: Contact sport‐related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates
TLDR
A. Hof, P. Giannakopoulos and A. Canuto (2011) Neuropathology and Applied Neurobiology37, 570–584.
View on Wiley
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