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Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent?
By mitigating the activities of proinflammatory mediators and pain producing neuropeptides released by activated synovial cells, HA may improve the symptoms of knee osteoarthritis (OA) by redressing this deficiency.
The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment
Results obtained clearly show that the in vitro synthesis of HA by these cells is influenced by the concentration and molecular weight of the HA in their extracellular environment.
Hyaluronan-phospholipid interactions.
Data show that phospholipids and HA interact and suggest they may also do so in vivo within the joint cavity, where both chemical species are present, giving rise to complexes which might exhibit peculiar lubricating and protective properties.
Osteoarthritis, genetic and molecular mechanisms
Cal calcium pentosan polysulfate (CaPPS) corrects many of the phenotypic imbalances in chondrocyte metabolism and promotes the synthesis of large PGs, thereby, reducing proteolytic and angiogenic activity within the joint space.
Induction of matrix metalloproteinase-2 and -3 activity in ovine nucleus pulposus cells grown in three-dimensional agarose gel culture by interleukin-1β: a potential pathway of disc degeneration
Evaluated MMP-2 (gelatinase-A) and M MP-3 (stromelysin) produced by cultured ovine nucleus pulposus cells stimulated with interleukin-1β indicated that elevated levels of proM MP-2 and proMMP-3 were present in media samples in response to the IL-1 β treatment.
Topographical analysis of the structural, biochemical and dynamic biomechanical properties of cartilage in an ovine model of osteoarthritis.
This study has highlighted the variable response of AC in different topographical regions of meniscectomized joints to the altered mechanical stresses introduced by this surgical procedure.
Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases
Calcium pentosan polysulfate (CaPPS), a chemically sulfated xylanopyranose from beechwood, is a multifaceted exosite inhibitor of the aggrecanases and protects cartilage againstaggrecan degradation.