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Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain.
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder that affects growth properties of neural-crest-derived cell populations. In addition, approximately one-half of NF1 patients exhibitExpand
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Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent?
BACKGROUND Hyaluronan, or hyaluronic acid (HA), is the major hydrodynamic nonprotein component of joint synovial fluid (SF). Its unique viscoelastic properties confer remarkable shock absorbing andExpand
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Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response.
Cross-coupling of active protein-1 (AP-1) and nuclear factor (NF)-kappaB has been reported. In the present study, we investigated the possibility that both of these two transcription factors mightExpand
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Morphological studies of the canine intervertebral disc. The assignment of the beagle to the achondroplastic classification.
The morphological development of the epiphyseal growth plate and intervertebral discs of newborn and nine-month-old beagles, greyhounds and dachshunds have been studied. On the basis of the cellularExpand
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Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases
Degradation of the cartilage proteoglycan aggrecan is a key early event in the development of osteoarthritis. Adamalysin with thrombospondin motifs (ADAMTS) −4 and ADAMTS‐5 are considered to be theExpand
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Osteoarthritis, genetic and molecular mechanisms
Osteoarthritis (OA) is the most common musculoskeletal disorder world-wide and has enormous social and economic consequences. OA is a multifactorial disorder in which ageing, genetic, hormonal andExpand
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Topographical analysis of the structural, biochemical and dynamic biomechanical properties of cartilage in an ovine model of osteoarthritis.
OBJECTIVE The relationship between the topographical variations in the structural, biochemical and dynamic biomechanical properties of articular cartilage (AC) before and 6 months after meniscectomyExpand
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The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment.
  • P. Ghosh
  • Medicine
  • Seminars in arthritis and rheumatism
  • 1 February 1999
OBJECTIVES Structure-modifying osteoarthritis (OA) drugs (SMOADs) may be defined as agents that reverse, retard, or stabilize the underlying pathology of OA, thereby providing symptomatic relief inExpand
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Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis
Osteoarthritis (OA), the commonest form of arthritis and a major cause of morbidity, is characterized by progressive degeneration of the articular cartilage. Along with increased production andExpand
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Induction of matrix metalloproteinase-2 and -3 activity in ovine nucleus pulposus cells grown in three-dimensional agarose gel culture by interleukin-1β: a potential pathway of disc degeneration
Abstract. Degeneration of the intervertebral disc is an important clinical problem, which often contributes to low back pain. Since approximately 80–90% of the general population will be subject toExpand
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