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Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF.
Results indicate that the addition of both FGF2 and VEGF to an acellular construct enhances an early mature vasculature, which opens prospects for (acellular) tissue-engineered constructs in conditions as ischaemic heart disease or diabetic ulcers. Expand
From molecules to matrix: construction and evaluation of molecularly defined bioscaffolds.
This chapter describes the fundamental aspects of the preparation of molecularly-defined scaffolds for soft tissue engineering, including the tissue response to the scaffolds after implantation, and animal studies of two potential applications of these scaffolds, i.e. for bladder and cartilage regeneration. Expand
The effect of Ethylene Oxide Sterilisation, Beta Irradiation and Gamma Irradiation on Collagen Fibril-Based Scaffolds.
Ethylene oxide (EtO) gassing and β- and γ-irradiation are currently used for sterilising collagen scaffolds. During the process, scaffolds may undergo chemical and physical alterations that mayExpand
Evaluation of collagen/heparin coated TCP/HA granules for long-term delivery of BMP-2
The local and sustained delivery system for B MP-2 developed in this study may be useful as a carrier for BMP-2 and could possibly enhance bone regeneration efficacy for the treatment of large bone defects. Expand
Correction: Tissue Engineering in Animal Models for Urinary Diversion: A Systematic Review
Tissue engineering and regenerative medicine (TERM) approaches may provide alternatives for gastrointestinal tissue in urinary diversion. To continue to clinically translatable studies, TERMExpand
Lyophilisomes as a new generation of drug delivery capsules.
Nanoparticulate drug delivery systems are currently explored to overcome critical challenges associated with classical administration forms. In this study, we present a drug delivery system based onExpand
Preparation and characterization of injectable fibrillar type I collagen and evaluation for pseudoaneurysm treatment in a pig model.
Although optimization is needed, an injectable collagen may be used as a therapeutic agent for femoral PSA treatment, as it formed a dense network and triggered (partial) local hemostasis in vivo. Expand
Urethral reconstruction of critical defects in rabbits using molecularly defined tubular type I collagen biomatrices: key issues in growth factor addition.
Tubular acellular type I collagen biomatrices were successful in repairing urethral lesions in artificial urethrals defects, and inclusion of GF has a profound effect on regenerative processes. Expand
Ureteral tissue engineering: where are we and how to proceed?
It is concluded that the available literature is inconclusive since the superiority of a specific scaffold has not been demonstrated and the latest developments of regenerative medicine have not been evaluated in ureteral tissue engineering yet. Expand
Organ-specific tubular and collagen-based composite scaffolds.
This study explored several methodologies for the construction of collagenous tubular scaffolds and films with defined (ultra)structure, length, diameter, orientation, and molecular composition and found handling and suturability were found adequate for tissue engineering applications. Expand