• Publications
  • Influence
The fate of competing beneficial mutations in an asexual population
In sexual populations, beneficial mutations that occur in different lineages may be recombined into a single lineage. In asexual populations, however, clones that carry such alternative beneficialExpand
  • 813
  • 49
Evolution of Swine H3N2 Influenza Viruses in the United States
ABSTRACT During 1998, severe outbreaks of influenza were observed in four swine herds in the United States. This event was unique because the causative agents, H3N2 influenza viruses, areExpand
  • 355
  • 28
The evolution of mutation rates: separating causes from consequences
Natural selection can adjust the rate of mutation in a population by acting on allelic variation affecting processes of DNA replication and repair. Because mutation is the ultimate source of theExpand
  • 470
  • 22
Evolution of high mutation rates in experimental populations of E. coli
Most mutations are likely to be deleterious, and so the spontaneous mutation rate is generally held at a very low value. Nonetheless, evolutionary theory predicts that high mutation rates can evolveExpand
  • 821
  • 17
  • PDF
THE PROBABILITY THAT BENEFICIAL MUTATIONS ARE LOST IN POPULATIONS WITH PERIODIC BOTTLENECKS
  • L. Wahl, P. Gerrish
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 December 2001
Abstract Population bottlenecks affect the dynamics of evolution, increasing the probability that beneficial mutations will be lost. Recent protocols for the experimental study of evolution involveExpand
  • 108
  • 14
Beneficial mutations and the dynamics of adaptation in asexual populations
We discuss the dynamics of adaptive evolution in asexual (clonal) populations. The classical ‘periodic selection’ model of clonal evolution assumed that beneficial mutations are very rare andExpand
  • 173
  • 13
  • PDF
Fitness Effects of Fixed Beneficial Mutations in Microbial Populations
Beneficial mutations are intuitively relevant to understanding adaptation, yet not all beneficial mutations are of consequence to the long-term evolutionary outcome of adaptation. Many beneficialExpand
  • 208
  • 12
Diminishing returns from mutation supply rate in asexual populations.
Mutator genotypes with increased mutation rates may be especially important in microbial evolution if genetic adaptation is generally limited by the supply of mutations. In experimental populationsExpand
  • 347
  • 6
  • PDF
Evolution of competitive fitness in experimental populations of E. coli: What makes one genotype a better competitor than another?
An important problem in microbial ecology is to identify those phenotypic attributes that are responsible for competitive fitness in a particular environment. Thousands of papers have been publishedExpand
  • 144
  • 6
  • PDF
Complete genetic linkage can subvert natural selection
The intricate adjustment of organisms to their environment demonstrates the effectiveness of natural selection. But Darwin himself recognized that certain biological features could limit thisExpand
  • 81
  • 5
  • PDF